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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Genome


Psychiatry related information on Genome


High impact information on Genome

  • Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses [11].
  • Both of these approaches have implicated multiple regions in the human and mouse genomes, which are currently being evaluated as harboring putative atopy genes [12].
  • FEN1 is a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions [13].
  • SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction [14].
  • Glycan production and modification comprise an estimated 1% of genes in the mammalian genome [15].

Chemical compound and disease context of Genome


Biological context of Genome


Anatomical context of Genome


Associations of Genome with chemical compounds

  • He has also turned out to be an important mutagen, one that presents a particular serious challenge to large genomes; it converts cytosine to uracil and guanine to an analogue of cytosine [31].
  • The mutant virus reverted to wild-type by a single base change to a serine codon at a frequency of approximately 2.5 x 10(-6), surprisingly low for a RNA genome [32].
  • All other restriction endonucleases tested (Mbo I, Mbo II, Hind III, Hin II+III and Hinf I), for which there are no closely spaced recognition sequences in the above mentioned regions of the SV40 genome, did not produce any significant amount of limit-digest DNA fragments from formaldehyde-fixed minichromosomes [33].
  • MeCP2 selectively binds CpG dinucleotides in the mammalian genome and mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (refs 12,13) [34].
  • How are these observations to be reconciled with the prevalent view of steroid receptors as gene control proteins regulating transcription at specific loci on the genome [35]?

Gene context of Genome

  • Loss of p53 function results in deficient global genomic repair (GGR), a subset of NER that targets and removes lesions from the whole genome [36].
  • These findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRCA1 in the control of recombination and of genome integrity [37].
  • This suggests that defects in the suppression of rearrangements involving divergent, repeated sequences may underlie the genome instability seen in BLM and WRN patients and in cancer cases associated with defects in these genes [38].
  • To better understand the cellular role of the RecQ-like DNA helicases, sgs1 mutations were analyzed for their effect on genome rearrangements [38].
  • A precise, oligonucleotide-directed deletion of UBI4 was constructed in vitro and substituted in the yeast genome in place of the wild-type allele. ubi4 deletion mutants are viable as vegetative cells, grow at wild-type rates, and contain wild-type levels of free ubiquitin under exponential growth conditions [39].

Analytical, diagnostic and therapeutic context of Genome

  • Restriction enzyme analyses demonstrated that, with the exception of Mov-4 and Mov-6 mice, no major rearrangements or deletions have occurred in the integrated proviral genomes [40].
  • Since the presence of DI genomes could not be detected by analytical sucrose gradient centrifugation in these VSV-infected cells, this minus strand leader RNA is apparently synthesized on the template formed by the exact 3' end of the antigenome RNA [41].
  • Southern blot analysis of the bovine genome indicated that one or possibly two genes hybridize to the cloned PLC-148 cDNA [42].
  • Sequence analysis shows it to be a novel cellular tyrosine protein kinase which is distinct from all others described to date. p56tck is encoded in LSTRA cells by a hybrid messenger RNA; approximately 200 nucleotides at the 5' end of the mRNA are identical to the 5' end of the genome of M-MuLV [43].
  • A specific protein of molecular weight (MW) approximately 55,000 (55K) was found recently by immunoprecipitation in all SV40 virus-transformed mammalian cells, in addition to the SV40 large T antigen (appoximately 94K) and small antigen (approximately 17K), which are the only proteins coded by the 'early half' of the SV40 genome [44].


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  15. A genetic approach to Mammalian glycan function. Lowe, J.B., Marth, J.D. Annu. Rev. Biochem. (2003) [Pubmed]
  16. A copper cofactor for the ethylene receptor ETR1 from Arabidopsis. Rodríguez, F.I., Esch, J.J., Hall, A.E., Binder, B.M., Schaller, G.E., Bleecker, A.B. Science (1999) [Pubmed]
  17. Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Kamtekar, S., Berman, A.J., Wang, J., Lázaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A. Mol. Cell (2004) [Pubmed]
  18. Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells. Sun, Y., Clark, E.A. J. Exp. Med. (1999) [Pubmed]
  19. Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I. Isolation, characterization, cell surface markers, and B-cell markers. Zeuthen, J., Klein, G., Ber, R., Masucci, G., Bisballe, S., Povey, S., Terasaki, P., Ralph, P. J. Natl. Cancer Inst. (1982) [Pubmed]
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  22. Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila. Bachtrog, D. Nat. Genet. (2003) [Pubmed]
  23. Right 25 bp terminus sequence of the nopaline T-DNA is essential for and determines direction of DNA transfer from agrobacterium to the plant genome. Wang, K., Herrera-Estrella, L., Van Montagu, M., Zambryski, P. Cell (1984) [Pubmed]
  24. alpha-Tubulin genes of Drosophila. Kalfayan, L., Wensink, P.C. Cell (1981) [Pubmed]
  25. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Stucki, M., Clapperton, J.A., Mohammad, D., Yaffe, M.B., Smerdon, S.J., Jackson, S.P. Cell (2005) [Pubmed]
  26. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region. Rawlins, D.R., Milman, G., Hayward, S.D., Hayward, G.S. Cell (1985) [Pubmed]
  27. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Dickins, R.A., Hemann, M.T., Zilfou, J.T., Simpson, D.R., Ibarra, I., Hannon, G.J., Lowe, S.W. Nat. Genet. (2005) [Pubmed]
  28. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Bohr, V.A., Smith, C.A., Okumoto, D.S., Hanawalt, P.C. Cell (1985) [Pubmed]
  29. Evidence that hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease. Bréchot, C., Nalpas, B., Couroucé, A.M., Duhamel, G., Callard, P., Carnot, F., Tiollais, P., Berthelot, P. N. Engl. J. Med. (1982) [Pubmed]
  30. Tissue-specific expression of two mRNA species transcribed from a single vimentin gene. Capetanaki, Y.G., Ngai, J., Flytzanis, C.N., Lazarides, E. Cell (1983) [Pubmed]
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  33. A stretch of "late" SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomes. Varshavsky, A.J., Sundin, O., Bohn, M. Cell (1979) [Pubmed]
  34. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U., Zoghbi, H.Y. Nat. Genet. (1999) [Pubmed]
  35. The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites. Yamamoto, K., Alberts, B. Cell (1975) [Pubmed]
  36. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Hartman, A.R., Ford, J.M. Nat. Genet. (2002) [Pubmed]
  37. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., Livingston, D.M. Cell (1997) [Pubmed]
  38. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Myung, K., Datta, A., Chen, C., Kolodner, R.D. Nat. Genet. (2001) [Pubmed]
  39. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Finley, D., Ozkaynak, E., Varshavsky, A. Cell (1987) [Pubmed]
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