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Gene Review:

SH - SH

Human respiratory syncytial virus

Karron, R.A. et al.

Karron, Buonagurio, Georgiu, Whitehead, Adamus, Clements-Mann, Harris, Randolph, Udem, Murphy, Sidhu,

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Disease relevance of SH

Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant [1].

Analytical, diagnostic and therapeutic context of SH

Northern blot analysis of cp-52 detected multiple unique read-through mRNAs containing SH and G sequences, consistent with a deletion mutation spanning the SH:G gene junction [1].
Sequence analysis of reverse-transcription-PCR-amplified fragments of this mutant revealed a large deletion spanning most of the coding sequences for the small hydrophobic (SH) and attachment (G) proteins [1].

References

Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant. Karron, R.A., Buonagurio, D.A., Georgiu, A.F., Whitehead, S.S., Adamus, J.E., Clements-Mann, M.L., Harris, D.O., Randolph, V.B., Udem, S.A., Murphy, B.R., Sidhu, M.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]

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