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Gene Review

ORF5  -  coat protein

Foxtail mosaic virus

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Disease relevance of ORF5

  • When compared to potex-, carla-, clostero- and capilloviruses, the ASPV genome organization appeared to be most closely related to that of potexviruses, but with a larger coat protein of M(r) 44K (ORF5) [1].

High impact information on ORF5

  • Four of the five proteins encoded by the Grapevine virus A (GVA) genome were screened using a green fluorescent protein (GFP)-based transient expression assay, and the expression product of ORF5 (protein p10) was identified as a suppressor of silencing [2].
  • Protein coded by ORF4 is the least conserved between both isolates (95% amino acid identity), whereas proteins coded by ORF3 and ORF5 are identical [3].


  1. Nucleotide sequences of apple stem pitting virus and of the coat protein gene of a similar virus from pear associated with vein yellows disease and their relationship with potex- and carlaviruses. Jelkmann, W. J. Gen. Virol. (1994) [Pubmed]
  2. Identification of an RNA-silencing suppressor in the genome of Grapevine virus A. Zhou, Z.S.h., Dell'Orco, M., Saldarelli, P., Turturo, C., Minafra, A., Martelli, G.P. J. Gen. Virol. (2006) [Pubmed]
  3. Complete sequence of the Pepino mosaic virus RNA genome. Aguilar, J.M., Hernández-Gallardo, M.D., Cenis, J.L., Lacasa, A., Aranda, M.A. Arch. Virol. (2002) [Pubmed]
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