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Gene Review

PYDC2  -  pyrin domain containing 2

Homo sapiens

Synonyms: POP2, Pyrin domain-containing protein 2, Pyrin-only protein 2, cPOP2
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Associations of PYDC2 with chemical compounds

  • TNF-alpha-stimulated and p65 (RelA)-induced NF-kappaB-dependent gene transcription is inhibited by POP2 in vitro by a mechanism involving changes in NF-kappaB nuclear import or distribution [1].


  1. Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. Bedoya, F., Sandler, L.L., Harton, J.A. J. Immunol. (2007) [Pubmed]
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