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Disease relevance of Tumor necrosis factor


Psychiatry related information on Tumor necrosis factor


High impact information on Tumor necrosis factor


Chemical compound and disease context of Tumor necrosis factor


Biological context of Tumor necrosis factor


Anatomical context of Tumor necrosis factor

  • In contrast, septic shock and cachexia may result from either acute or chronic systemic activation of monocytes, resulting in the widespread release of TNF secretory component into the circulation of the affected individual [3].
  • The increase in TNF in Timp3(-/-) mice culminated in hepatic lymphocyte infiltration and necrosis, features that are also seen in chronic active hepatitis in humans [19].
  • The latent membrane protein 1 (LMP1) of EBV-infected cells plays a central part in this process by mimicking members of the family of tumor necrosis factor (TNF) receptors, thereby transmitting growth signals from the cell membrane to the nucleus through cytoplasmic TNF-receptor-associated factors (TRAFs) [27].
  • Tumor necrosis factor (TNF) is synthesized by macrophages exposed to endotoxin [28].
  • We show here that TNF markedly stimulates production of GM-CSF messenger RNA and protein in normal human lung fibroblasts and vascular endothelial cells, and in cells of several malignant tissues [28].

Associations of Tumor necrosis factor with other chemical compounds


Gene context of Tumor necrosis factor


Analytical, diagnostic and therapeutic context of Tumor necrosis factor


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  4. Tumor necrosis factor-alpha and disease progression in multiple sclerosis. Liblau, R.S., Fugger, L. N. Engl. J. Med. (1992) [Pubmed]
  5. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Smith, C.A., Gruss, H.J., Davis, T., Anderson, D., Farrah, T., Baker, E., Sutherland, G.R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. Cell (1993) [Pubmed]
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  15. Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex. Seilhean, D., Kobayashi, K., He, Y., Uchihara, T., Rosenblum, O., Katlama, C., Bricaire, F., Duyckaerts, C., Hauw, J.J. Acta Neuropathol. (1997) [Pubmed]
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  17. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Janes, K.A., Gaudet, S., Albeck, J.G., Nielsen, U.B., Lauffenburger, D.A., Sorger, P.K. Cell (2006) [Pubmed]
  18. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Chang, L., Kamata, H., Solinas, G., Luo, J.L., Maeda, S., Venuprasad, K., Liu, Y.C., Karin, M. Cell (2006) [Pubmed]
  19. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Mohammed, F.F., Smookler, D.S., Taylor, S.E., Fingleton, B., Kassiri, Z., Sanchez, O.H., English, J.L., Matrisian, L.M., Au, B., Yeh, W.C., Khokha, R. Nat. Genet. (2004) [Pubmed]
  20. Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Eichhorst, S.T., Krueger, A., Müerköster, S., Fas, S.C., Golks, A., Gruetzner, U., Schubert, L., Opelz, C., Bilzer, M., Gerbes, A.L., Krammer, P.H. Nat. Med. (2004) [Pubmed]
  21. Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock. Gadina, M., Bertini, R., Mengozzi, M., Zandalasini, M., Mantovani, A., Ghezzi, P. J. Exp. Med. (1991) [Pubmed]
  22. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Lügering, A., Schmidt, M., Lügering, N., Pauels, H.G., Domschke, W., Kucharzik, T. Gastroenterology (2001) [Pubmed]
  23. Enhanced sensitivity of human colon tumor cell lines in vitro in response to thermochemoimmunotherapy. Klostergaard, J., Leroux, E., Siddik, Z.H., Khodadadian, M., Tomasovic, S.P. Cancer Res. (1992) [Pubmed]
  24. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Is Required for Tumor Necrosis Factor {alpha}-Mediated Sensitization of Human Breast Cancer Cells to Chemotherapy. Xu, J., Zhou, J.Y., Wu, G.S. Cancer Res. (2006) [Pubmed]
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  27. Epstein-Barr virus and a cellular signaling pathway in lymphomas from immunosuppressed patients. Liebowitz, D. N. Engl. J. Med. (1998) [Pubmed]
  28. Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Munker, R., Gasson, J., Ogawa, M., Koeffler, H.P. Nature (1986) [Pubmed]
  29. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Rüegg, C., Yilmaz, A., Bieler, G., Bamat, J., Chaubert, P., Lejeune, F.J. Nat. Med. (1998) [Pubmed]
  30. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Wang, C.Y., Mayo, M.W., Baldwin, A.S. Science (1996) [Pubmed]
  31. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. Cassatella, M.A., Meda, L., Gasperini, S., Calzetti, F., Bonora, S. J. Exp. Med. (1994) [Pubmed]
  32. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. Strelow, A., Bernardo, K., Adam-Klages, S., Linke, T., Sandhoff, K., Krönke, M., Adam, D. J. Exp. Med. (2000) [Pubmed]
  33. Pharmacological stimulation of the cholinergic antiinflammatory pathway. Bernik, T.R., Friedman, S.G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C.J., Ivanova, S.M., Tracey, K.J. J. Exp. Med. (2002) [Pubmed]
  34. A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles. Mateo, T., Naim Abu Nabah, Y., Losada, M., Estellés, R., Company, C., Bedrina, B., Cerdá-Nicolás, J.M., Poole, S., Jose, P.J., Cortijo, J., Morcillo, E.J., Sanz, M.J. Blood (2007) [Pubmed]
  35. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model. Elsaid, K.A., Machan, J.T., Waller, K., Fleming, B.C., Jay, G.D. Arthritis Rheum. (2009) [Pubmed]
  36. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Browning, J.L., Ngam-ek, A., Lawton, P., DeMarinis, J., Tizard, R., Chow, E.P., Hession, C., O'Brine-Greco, B., Foley, S.F., Ware, C.F. Cell (1993) [Pubmed]
  37. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Hsu, H., Xiong, J., Goeddel, D.V. Cell (1995) [Pubmed]
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