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Gene Review

CRYGN  -  crystallin, gamma N

Homo sapiens

Synonyms: Gamma-N-crystallin, Gamma-crystallin N
 
 
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Disease relevance of CRYGN

  • Cell interposition in glomerular capillary walls in cryoglobulinemic glomerulonephritis (CRYGN). Ultrastructural investigation of 23 cases [1].
 

High impact information on CRYGN

  • Thirty-three renal biopsies of patients affected by cryoglobulinemic glomerulonephritis (CRYGN) were investigated by electron microscopy, paying particular attention to the nature of cells responsible of glomerular hypercellularity, the presence and site of electron-dense deposits and their ultrastructural characteristics [2].
  • Despite similarities under light microscopy, CRYGN is therefore rather different from idiopathic membranoproliferative GN because of the prevalence of exudative changes, mainly due to monocyte infiltration, over proliferative lesions [1].

References

  1. Cell interposition in glomerular capillary walls in cryoglobulinemic glomerulonephritis (CRYGN). Ultrastructural investigation of 23 cases. Mazzucco, G., Monga, G., Casanova, S., Cagnoli, L. Ultrastructural pathology. (1986) [Pubmed]
  2. Ultrastructural glomerular findings in cryoglobulinemic glomerulonephritis. Monga, G., Mazzucco, G., Casanova, S., Boero, R., Cagnoli, L., Barbiano di Belgiojoso, G., Confalonieri, R. Applied pathology. (1987) [Pubmed]
 
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