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Gene Review

ZNF366  -  zinc finger protein 366

Homo sapiens

Synonyms: FLJ39796, Zinc finger protein 366
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High impact information on ZNF366

  • Two of the novel genes contain zinc finger domains and are designated ZNF366 and ZNF367 [1].
  • Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen [2].
  • The interaction between ZNF366 and ERalpha has been confirmed in vitro and in vivo, and is mediated by the zinc finger domains of the two proteins [2].


  1. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gilligan, P., Brenner, S., Venkatesh, B. Gene (2002) [Pubmed]
  2. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Lopez-Garcia, J., Periyasamy, M., Thomas, R.S., Christian, M., Leao, M., Jat, P., Kindle, K.B., Heery, D.M., Parker, M.G., Buluwela, L., Kamalati, T., Ali, S. Nucleic Acids Res. (2006) [Pubmed]
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