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Gene Review:

unc-14 - Protein UNC-14

Caenorhabditis elegans

Ogura, K. et al., Ogura, K. et al.

Ogura, Goshima,

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High impact information on unc-14

The unc-14 gene encodes a novel protein of 665 amino acids, and is coexpressed with the unc-51 gene in the cell bodies and axons of almost all neurons including DD/VD and hermaphrodite-specific neurons [1].

Associations of unc-14 with chemical compounds

Here we observed that, in unc-51 and unc-14 mutants, UNC-5, the receptor for axon-guidance protein Netrin/UNC-6, abnormally localized in neuronal cell bodies [2].

References

The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Ogura, K., Shirakawa, M., Barnes, T.M., Hekimi, S., Ohshima, Y. Genes Dev. (1997) [Pubmed]
The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Ogura, K., Goshima, Y. Development (2006) [Pubmed]

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