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Gene Review

mpk-2  -  Protein MPK-2

Caenorhabditis elegans

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High impact information on mpk-2

  • Two C. elegans MAP kinase genes, mpk-1 and mpk-2 (mpk, MAP kinase), were cloned using degenerate oligonucleotide primers and PCR amplification; in parallel, genes involved in vulval induction were identified by screening for mutations that suppress the vulval defects caused by an activated let-60 ras gene [1].


  1. A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Lackner, M.R., Kornfeld, K., Miller, L.M., Horvitz, H.R., Kim, S.K. Genes Dev. (1994) [Pubmed]
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