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Gene Review: 

nfi-1  -  Protein NFI-1

Caenorhabditis elegans

 
 
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High impact information on nfi-1

  • In contrast, the C. elegans nfi-1 gene has four phased introns interrupting this DNA-binding, domain-encoding exon, and the last exon extends 213 bp past the splice site used in all four murine genes [1].
  • The phenotype of nfi-1 null worms indicates that NFI functions in multiple developmental and behavioral systems in C. elegans, likely regulating genes that function in motility, egg-laying, pharyngeal pumping and lifespan maintenance [2].
  • RESULTS: C. elegans NFI protein (CeNFI) binds specifically to the same NFI-binding site recognized by vertebrate NFIs. nfi-1 encodes alternatively-spliced, maternally-inherited transcripts that are expressed at the single cell stage, during embryogenesis, and in adult muscles, neurons and gut cells [2].

References

  1. Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals. Fletcher, C.F., Jenkins, N.A., Copeland, N.G., Chaudhry, A.Z., Gronostajski, R.M. Mamm. Genome (1999) [Pubmed]
  2. nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival. Lazakovitch, E., Kalb, J.M., Matsumoto, R., Hirono, K., Kohara, Y., Gronostajski, R.M. BMC Dev. Biol. (2005) [Pubmed]
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