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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Embryonic Development

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Disease relevance of Embryonic Development


Psychiatry related information on Embryonic Development


High impact information on Embryonic Development


Chemical compound and disease context of Embryonic Development


Biological context of Embryonic Development


Anatomical context of Embryonic Development


Associations of Embryonic Development with chemical compounds

  • FGFR2 is a member of the tyrosine kinase receptor superfamily, having a high affinity for peptides that signal the transduction pathways for mitogenesis, cellular differentiation and embryogenesis [30].
  • Cholesterol, hedgehog and embryogenesis [31].
  • The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis [32].
  • The importance of an adequate intracellular folate pool for normal embryogenesis has long been recognized in humans and experimental animals [33].
  • H2A, which generally lacks this amino acid, contains methionine only in a protein variant which is synthesized in early sea urchin embryogenesis [34].

Gene context of Embryonic Development


Analytical, diagnostic and therapeutic context of Embryonic Development


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  3. Fetal alcohol syndrome: embryogenesis in a mouse model. Sulik, K.K., Johnston, M.C., Webb, M.A. Science (1981) [Pubmed]
  4. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Yeh, W.C., Pompa, J.L., McCurrach, M.E., Shu, H.B., Elia, A.J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W.S., Lowe, S.W., Goeddel, D.V., Mak, T.W. Science (1998) [Pubmed]
  5. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Covello, K.L., Kehler, J., Yu, H., Gordan, J.D., Arsham, A.M., Hu, C.J., Labosky, P.A., Simon, M.C., Keith, B. Genes Dev. (2006) [Pubmed]
  6. A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Chuang, C.F., Bargmann, C.I. Genes Dev. (2005) [Pubmed]
  7. A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis. Ott, M.O., Bullock, S.L. Dev. Genes Evol. (2001) [Pubmed]
  8. Permanent impairment in the feeding behavior of grayling (Thymallus thymallus) exposed to methylmercury during embryogenesis. Fjeld, E., Haugen, T.O., Vøllestad, L.A. Sci. Total Environ. (1998) [Pubmed]
  9. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Forsyth, N.R., Wright, W.E., Shay, J.W. Differentiation (2002) [Pubmed]
  10. Regulation of T cell fate by Notch. Robey, E. Annu. Rev. Immunol. (1999) [Pubmed]
  11. Regulation of lymphocyte survival by the bcl-2 gene family. Cory, S. Annu. Rev. Immunol. (1995) [Pubmed]
  12. Retinoids in embryonal development. Ross, S.A., McCaffery, P.J., Drager, U.C., De Luca, L.M. Physiol. Rev. (2000) [Pubmed]
  13. Mechanism of action and in vivo role of platelet-derived growth factor. Heldin, C.H., Westermark, B. Physiol. Rev. (1999) [Pubmed]
  14. Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Ko, M.A., Rosario, C.O., Hudson, J.W., Kulkarni, S., Pollett, A., Dennis, J.W., Swallow, C.J. Nat. Genet. (2005) [Pubmed]
  15. Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. Kuo, C.J., Mendel, D.B., Hansen, L.P., Crabtree, G.R. EMBO J. (1991) [Pubmed]
  16. Feedback regulation of cell-substratum adhesion by integrin-mediated intracellular Ca2+ signaling. Sjaastad, M.D., Angres, B., Lewis, R.S., Nelson, W.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. Nervi, C., Borello, U., Fazi, F., Buffa, V., Pelicci, P.G., Cossu, G. Cancer Res. (2001) [Pubmed]
  18. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. Cianetti, L., Di Cristofaro, A., Zappavigna, V., Bottero, L., Boccoli, G., Testa, U., Russo, G., Boncinelli, E., Peschle, C. Nucleic Acids Res. (1990) [Pubmed]
  19. Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis. Korkina, L.G., Deeva, I.B., De Biase, A., Iaccarino, M., Oral, R., Warnau, M., Pagano, G. Carcinogenesis (2000) [Pubmed]
  20. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Brownlie, A., Donovan, A., Pratt, S.J., Paw, B.H., Oates, A.C., Brugnara, C., Witkowska, H.E., Sassa, S., Zon, L.I. Nat. Genet. (1998) [Pubmed]
  21. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M., Horvitz, H.R. Cell (1993) [Pubmed]
  22. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Satokata, I., Maas, R. Nat. Genet. (1994) [Pubmed]
  23. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Imamoto, A., Soriano, P. Cell (1993) [Pubmed]
  24. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Li, Q.Y., Newbury-Ecob, R.A., Terrett, J.A., Wilson, D.I., Curtis, A.R., Yi, C.H., Gebuhr, T., Bullen, P.J., Robson, S.C., Strachan, T., Bonnet, D., Lyonnet, S., Young, I.D., Raeburn, J.A., Buckler, A.J., Law, D.J., Brook, J.D. Nat. Genet. (1997) [Pubmed]
  25. Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Ruiz i Altaba, A., Melton, D.A. Cell (1989) [Pubmed]
  26. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Ng, D., Thakker, N., Corcoran, C.M., Donnai, D., Perveen, R., Schneider, A., Hadley, D.W., Tifft, C., Zhang, L., Wilkie, A.O., van der Smagt, J.J., Gorlin, R.J., Burgess, S.M., Bardwell, V.J., Black, G.C., Biesecker, L.G. Nat. Genet. (2004) [Pubmed]
  27. Parental DNA strands segregate randomly during embryonic development of Caenorhabditis elegans. Ito, K., McGhee, J.D. Cell (1987) [Pubmed]
  28. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Maroto, M., Reshef, R., Münsterberg, A.E., Koester, S., Goulding, M., Lassar, A.B. Cell (1997) [Pubmed]
  29. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., Le Meur, M. Nat. Genet. (1996) [Pubmed]
  30. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Jabs, E.W., Li, X., Scott, A.F., Meyers, G., Chen, W., Eccles, M., Mao, J.I., Charnas, L.R., Jackson, C.E., Jaye, M. Nat. Genet. (1994) [Pubmed]
  31. Cholesterol, hedgehog and embryogenesis. Herz, J., Willnow, T.E., Farese, R.V. Nat. Genet. (1997) [Pubmed]
  32. Three-dimensional structure of a complex between the death domains of Pelle and Tube. Xiao, T., Towb, P., Wasserman, S.A., Sprang, S.R. Cell (1999) [Pubmed]
  33. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Piedrahita, J.A., Oetama, B., Bennett, G.D., van Waes, J., Kamen, B.A., Richardson, J., Lacey, S.W., Anderson, R.G., Finnell, R.H. Nat. Genet. (1999) [Pubmed]
  34. The DNA sequence of sea urchin (S. purpuratus) H2A, H2B and H3 histone coding and spacer regions. Sures, I., Lowry, J., Kedes, L.H. Cell (1978) [Pubmed]
  35. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Penton, A., Chen, Y., Staehling-Hampton, K., Wrana, J.L., Attisano, L., Szidonya, J., Cassill, J.A., Massagué, J., Hoffmann, F.M. Cell (1994) [Pubmed]
  36. The localization and regulation of Antennapedia protein expression in Drosophila embryos. Carroll, S.B., Laymon, R.A., McCutcheon, M.A., Riley, P.D., Scott, M.P. Cell (1986) [Pubmed]
  37. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Yamauchi, T., Oike, Y., Kamon, J., Waki, H., Komeda, K., Tsuchida, A., Date, Y., Li, M.X., Miki, H., Akanuma, Y., Nagai, R., Kimura, S., Saheki, T., Nakazato, M., Naitoh, T., Yamamura, K., Kadowaki, T. Nat. Genet. (2002) [Pubmed]
  38. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Marquis, S.T., Rajan, J.V., Wynshaw-Boris, A., Xu, J., Yin, G.Y., Abel, K.J., Weber, B.L., Chodosh, L.A. Nat. Genet. (1995) [Pubmed]
  39. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Wright, E., Hargrave, M.R., Christiansen, J., Cooper, L., Kun, J., Evans, T., Gangadharan, U., Greenfield, A., Koopman, P. Nat. Genet. (1995) [Pubmed]
  40. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Partanen, J., Schwartz, L., Rossant, J. Genes Dev. (1998) [Pubmed]
  41. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Mark, M., Ghyselinck, N.B., Chambon, P. Annu. Rev. Pharmacol. Toxicol. (2006) [Pubmed]
  42. Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1. Roberts, A.B., Roche, N.S., Winokur, T.S., Burmester, J.K., Sporn, M.B. J. Clin. Invest. (1992) [Pubmed]
  43. Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila. Garzino, V., Pereira, A., Laurenti, P., Graba, Y., Levis, R.W., Le Parco, Y., Pradel, J. EMBO J. (1992) [Pubmed]
  44. Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. Crawford, A.W., Pino, J.D., Beckerle, M.C. J. Cell Biol. (1994) [Pubmed]
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