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Gene Review:

mex-6 - Protein MEX-6

Caenorhabditis elegans

Tenlen, J.R. et al., Schubert, C.M. et al.

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High impact information on mex-6

We provide evidence that two nearly identical genes, mex-5 and mex-6, link PAR asymmetry to those subsequent protein asymmetries [1].
We propose that the suppression of the Mex phenotype by reducing pos-1(+) is due to decreased repression of mex-6 translation [2].

Physical interactions of mex-6

We discovered that reducing the dosage of pos-1(+) can suppress the Mex phenotype of mex-5(-) embryos and that POS-1 binds the 3'-UTR of mex-6 [2].

References

MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos. Schubert, C.M., Lin, R., de Vries, C.J., Plasterk, R.H., Priess, J.R. Mol. Cell (2000) [Pubmed]
Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis. Tenlen, J.R., Schisa, J.A., Diede, S.J., Page, B.D. Genetics (2006) [Pubmed]

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