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Gene Review

mex-5  -  Protein MEX-5

Caenorhabditis elegans

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High impact information on mex-5

  • Their mutant phenotype and that of mex-5 mutants can be suppressed by reducing Ras/Map kinase signaling [1].
  • We provide evidence that two nearly identical genes, mex-5 and mex-6, link PAR asymmetry to those subsequent protein asymmetries [2].
  • Embryos from mex-5 single-mutant mothers are inviable due to the misexpression of SKN-1, a transcription factor that can specify mesoderm and endoderm [3].

Physical interactions of mex-5

  • We discovered that reducing the dosage of pos-1(+) can suppress the Mex phenotype of mex-5(-) embryos and that POS-1 binds the 3'-UTR of mex-6 [3].


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