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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cog-1  -  Protein COG-1

Caenorhabditis elegans

 
 
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High impact information on cog-1

  • We positionally cloned cog-1 and found that it encodes a homeobox protein most similar to the mammalian GTX and Nkx6.1 proteins [1].
  • We report the characterization of the cog-1 gene, mutations in which cause novel phenotypes in late patterning in vulval lineages, establishment of the vulva-uterine connection, development and function of the spermathecal-uterine junction, and the development of vas deferens-proctodeal connection in the male [1].
  • We show that G.U base pairing is tolerated in the 'seed' region of the lsy-6 miRNA interaction with its in vivo target cog-1, and that 6- to 8-base-pair perfect seed pairing is not a generally reliable predictor for an interaction of lsy-6 with a 3' untranslated region (UTR) [2].

References

  1. Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. Palmer, R.E., Inoue, T., Sherwood, D.R., Jiang, L.I., Sternberg, P.W. Dev. Biol. (2002) [Pubmed]
  2. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Didiano, D., Hobert, O. Nat. Struct. Mol. Biol. (2006) [Pubmed]
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