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Gene Review

ceh-21  -  Protein CEH-21

Caenorhabditis elegans

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High impact information on homeobox

  • How the homeobox genes evolved during and after the main radiation of the bilaterians remains poorly understood, as only a few animal genomes have been sequenced completely [1].
  • pha-2 is the Caenorhabditis elegans homolog of the vertebrate homeobox gene Hex [2].
  • We positionally cloned cog-1 and found that it encodes a homeobox protein most similar to the mammalian GTX and Nkx6.1 proteins [3].
  • One such gene, the LIM homeobox gene ttx-3, is known to be involved in the specification of the AIY neuronal subtype [4].


  1. Remodelling of the homeobox gene complement in the tunicate Oikopleura dioica. Edvardsen, R.B., Seo, H.C., Jensen, M.F., Mialon, A., Mikhaleva, J., Bjordal, M., Cartry, J., Reinhardt, R., Weissenbach, J., Wincker, P., Chourrout, D. Curr. Biol. (2005) [Pubmed]
  2. Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Mörck, C., Axäng, C., Goksör, M., Pilon, M. Dev. Biol. (2006) [Pubmed]
  3. Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. Palmer, R.E., Inoue, T., Sherwood, D.R., Jiang, L.I., Sternberg, P.W. Dev. Biol. (2002) [Pubmed]
  4. Developmental regulation of whole cell capacitance and membrane current in identified interneurons in C. elegans. Faumont, S., Boulin, T., Hobert, O., Lockery, S.R. J. Neurophysiol. (2006) [Pubmed]
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