Gene Review:
pac-1 - Protein PAC-1
Caenorhabditis elegans
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High impact information on C04D8.1
- The Bcr-like domain of CeGAP exhibited activity not only on members of the C. elegans and human Rho subfamily but surprisingly also on C. elegans Ras protein (let-60), human Ras, and Rab3A [1].
- CeGAP is therefore the first GTPase-activating protein acting on Ras-related proteins across different subfamilies [1].
References
- Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhabditis elegans. Chen, W., Blanc, J., Lim, L. J. Biol. Chem. (1994) [Pubmed]
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