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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gpr-2  -  Protein GPR-2

Caenorhabditis elegans

 
 
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High impact information on gpr-2

  • The loss of spindle asymmetry after RNAi of gpr-1 and gpr-2 appears to be the result of weakened pulling forces acting on the poles [1].
  • RNAi depletion of gpr-1 and gpr-2, homologs of mammalian AGS3 and Drosophila PINS (receptor-independent G protein regulators), results in a phenotype identical to that of embryos depleted of both GPA-16 and GOA-1; the first cleavage is symmetric, but polarity is not affected [1].

References

  1. Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo. Gotta, M., Dong, Y., Peterson, Y.K., Lanier, S.M., Ahringer, J. Curr. Biol. (2003) [Pubmed]
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