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Gene Review:

cut-6 - Protein CUT-6

Caenorhabditis elegans

Muriel, J.M. et al.

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Disease relevance of cuticulin

A recombinant fragment of M142.2 was expressed in Escherichia coli and used to raise an antiserum [1].

High impact information on cuticulin

Loss-of-function of M142.2 by RNAi resulted in a novel phenotype: dumpy dauers which lacked alae [1].

Analytical, diagnostic and therapeutic context of cuticulin

Immunohistochemistry using the antiserum localized M142.2 to the periphery of the alae of L1 and dauers, forming two longitudinal ribbons over the hypodermal cells [1].

References

M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Muriel, J.M., Brannan, M., Taylor, K., Johnstone, I.L., Lithgow, G.J., Tuckwell, D. Dev. Biol. (2003) [Pubmed]

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