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Gene Review:

cut-1 - Protein CUT-1

Caenorhabditis elegans

Lewis, E. et al., De Giorgi, C. et al., Timinouni, M. et al.

De Giorgi, De Luca, Lamberti,

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High impact information on cuticulin

The protein shows very high homology with CECUT-1, the product of the C. elegans gene cut-1 and with other cuticlin proteins of nematodes [1].
Studies on the expression of this gene demonstrated that, while in the adult females cut-1 is not expressed, the removal of the introns occurs in the eggs [2].
Despite the fact that no transcripts could be detected in mature adult worms by RT-PCR, immuno-gold microscopy revealed staining of the microfilarial cuticle within the uterus of the adult female worm, suggesting that other cut-1-like genes are present in Brugia [3].

Analytical, diagnostic and therapeutic context of cuticulin

A fragment of a cut-1 like gene from the filarial nematode Brugia pahangi (designated Bp-cut-1) was isolated by PCR from genomic DNA [3].

References

cut-1-like genes of Ascaris lumbricoides. Timinouni, M., Bazzicalupo, P. Gene (1997) [Pubmed]
A silent trans-splicing signal in the cuticlin-encoding gene of the plant-parasitic nematode Meloidogyne artiellia. De Giorgi, C., De Luca, F., Lamberti, F. Gene (1996) [Pubmed]
cut-1-like genes are present in the filarial nematodes, Brugia pahangi and Brugia malayi, and, as in other nematodes, code for components of the cuticle. Lewis, E., Hunter, S.J., Tetley, L., Nunes, C.P., Bazzicalupo, P., Devaney, E. Mol. Biochem. Parasitol. (1999) [Pubmed]

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