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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

zyg-8  -  Protein ZYG-8

Caenorhabditis elegans

 
 
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High impact information on zyg-8

  • zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly [1].
  • We identified the molecular nature of the zyg-8 locus in the course of a large-scale RNAi-based functional genomics screen [2].
 

Biological context of zyg-8

  • Here, we show that zyg-8 plays a key role in spindle positioning during asymmetric division of one-cell stage C. elegans embryos by promoting microtubule assembly during anaphase [1].

References

  1. zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly. Gönczy, P., Bellanger, J.M., Kirkham, M., Pozniakowski, A., Baumer, K., Phillips, J.B., Hyman, A.A. Dev. Cell (2001) [Pubmed]
  2. Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos. Gönczy, P., Grill, S., Stelzer, E.H., Kirkham, M., Hyman, A.A. Novartis Found. Symp. (2001) [Pubmed]
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