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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Anaphase

  • The second modification involved destruction of the cyclin at about the time of white spot appearance, just as would have occurred at the metaphase/anaphase transition in the natural environment of a cleaving sea urchin embryo [1].

Psychiatry related information on Anaphase


High impact information on Anaphase

  • Besides securin, Sgo1, a protein essential for protection of centromeric cohesion during anaphase I, is also destabilized in mnd2delta cells [3].
  • Here, we show that CDK phosphorylation of the essential licensing factor Cdc6 stabilizes it by preventing its association with the anaphase promoting complex/cyclosome (APC/C) [4].
  • Our results provide the first direct evidence that SMC1beta acts as a chiasma binder in mammals, stabilizing sites of exchange until anaphase [5].
  • Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase [6].
  • Levels of both APC and CDX2 were significantly lower in the distal colon, which caused high anaphase bridge index (ABI) associated with a higher frequency of loss of heterozygosity (LOH) at Apc [7].

Biological context of Anaphase


Anatomical context of Anaphase


Associations of Anaphase with chemical compounds

  • Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast [18].
  • Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein [19].
  • The cysteine protease separase triggers anaphase onset by cleaving chromosome-bound cohesin [20].
  • Depolymerization of spindle microtubules by nocodazole also reversibly blocked anaphase onset and the sustained Cai elevation, but did not block transients [21].
  • Co-injection of EGTA or 1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA) with fura-2 in calcium-free medium, but not in calcium containing medium, blocked both anaphase and the sustained Cai elevation in almost all cases [21].

Gene context of Anaphase


Analytical, diagnostic and therapeutic context of Anaphase


  1. Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs. Pines, J., Hunt, T. EMBO J. (1987) [Pubmed]
  2. Inhibition of anaphase spindle elongation in vitro by a peptide antibody that recognizes kinesin motor domain. Hogan, C.J., Wein, H., Wordeman, L., Scholey, J.M., Sawin, K.E., Cande, W.Z. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Penkner, A.M., Prinz, S., Ferscha, S., Klein, F. Cell (2005) [Pubmed]
  4. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Mailand, N., Diffley, J.F. Cell (2005) [Pubmed]
  5. SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction. Hodges, C.A., Revenkova, E., Jessberger, R., Hassold, T.J., Hunt, P.A. Nat. Genet. (2005) [Pubmed]
  6. Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase. Sullivan, M., Higuchi, T., Katis, V.L., Uhlmann, F. Cell (2004) [Pubmed]
  7. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003) [Pubmed]
  8. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich, S., Tomkiel, J., Earnshaw, W., Hieter, P. Cell (1995) [Pubmed]
  9. Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Alexandru, G., Uhlmann, F., Mechtler, K., Poupart, M.A., Nasmyth, K. Cell (2001) [Pubmed]
  10. Recycling the cell cycle: cyclins revisited. Murray, A.W. Cell (2004) [Pubmed]
  11. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Bhat, M.A., Philp, A.V., Glover, D.M., Bellen, H.J. Cell (1996) [Pubmed]
  12. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Abrieu, A., Magnaghi-Jaulin, L., Kahana, J.A., Peter, M., Castro, A., Vigneron, S., Lorca, T., Cleveland, D.W., Labbé, J.C. Cell (2001) [Pubmed]
  13. Asymmetric accumulation of Ash1p in postanaphase nuclei depends on a myosin and restricts yeast mating-type switching to mother cells. Bobola, N., Jansen, R.P., Shin, T.H., Nasmyth, K. Cell (1996) [Pubmed]
  14. Splitting the chromosome: cutting the ties that bind sister chromatids. Nasmyth, K., Peters, J.M., Uhlmann, F. Science (2000) [Pubmed]
  15. Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae. Lew, D.J. Curr. Opin. Genet. Dev. (2000) [Pubmed]
  16. The cohesion protein MEI-S332 localizes to condensed meiotic and mitotic centromeres until sister chromatids separate. Moore, D.P., Page, A.W., Tang, T.T., Kerrebrock, A.W., Orr-Weaver, T.L. J. Cell Biol. (1998) [Pubmed]
  17. The coordination of centrosome reproduction with nuclear events of the cell cycle in the sea urchin zygote. Hinchcliffe, E.H., Cassels, G.O., Rieder, C.L., Sluder, G. J. Cell Biol. (1998) [Pubmed]
  18. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Uhlmann, F., Wernic, D., Poupart, M.A., Koonin, E.V., Nasmyth, K. Cell (2000) [Pubmed]
  19. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham, C.H., Glover, D.M. Genes Dev. (1991) [Pubmed]
  20. Multiple roles for separase auto-cleavage during the G2/M transition. Papi, M., Berdougo, E., Randall, C.L., Ganguly, S., Jallepalli, P.V. Nat. Cell Biol. (2005) [Pubmed]
  21. Intracellular free calcium and mitosis in mammalian cells: anaphase onset is calcium modulated, but is not triggered by a brief transient. Tombes, R.M., Borisy, G.G. J. Cell Biol. (1989) [Pubmed]
  22. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M., Nasmyth, K. Cell (1998) [Pubmed]
  23. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Stegmeier, F., Visintin, R., Amon, A. Cell (2002) [Pubmed]
  24. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Shou, W., Seol, J.H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z.W., Jang, J., Shevchenko, A., Charbonneau, H., Deshaies, R.J. Cell (1999) [Pubmed]
  25. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Irniger, S., Piatti, S., Michaelis, C., Nasmyth, K. Cell (1995) [Pubmed]
  26. Interzone microtubule behavior in late anaphase and telophase spindles. Saxton, W.M., McIntosh, J.R. J. Cell Biol. (1987) [Pubmed]
  27. Biotin-tubulin incorporates into kinetochore fiber microtubules during early but not late anaphase. Wadsworth, P., Shelden, E., Rupp, G., Rieder, C.L. J. Cell Biol. (1989) [Pubmed]
  28. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. Trinkle-Mulcahy, L., Andersen, J., Lam, Y.W., Moorhead, G., Mann, M., Lamond, A.I. J. Cell Biol. (2006) [Pubmed]
  29. A postprophase topoisomerase II-dependent chromatid core separation step in the formation of metaphase chromosomes. Giménez-Abián, J.F., Clarke, D.J., Mullinger, A.M., Downes, C.S., Johnson, R.T. J. Cell Biol. (1995) [Pubmed]
  30. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. Pai, C.Y., Chen, H.K., Sheu, H.L., Yeh, N.H. J. Cell. Sci. (1995) [Pubmed]
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