Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

cyk-4 - Protein CYK-4

Caenorhabditis elegans

Raich, W.B. et al., Kuwabara, P.E. et al.

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High impact information on cyk-4

We find that the activity and expression of ptc-1 is essentially confined to the germ line and its progenitors. ptc-1 null mutants are sterile with multinucleate germ cells arising from a probable cytokinesis defect [1].
Time-lapse recordings and microtubule staining reveal that the cytokinesis defect is preceded by the dissociation of the midzone microtubules [2].

References

A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Kuwabara, P.E., Lee, M.H., Schedl, T., Jefferis, G.S. Genes Dev. (2000) [Pubmed]
Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Raich, W.B., Moran, A.N., Rothman, J.H., Hardin, J. Mol. Biol. Cell (1998) [Pubmed]

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