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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ark-1  -  Protein ARK-1

Caenorhabditis elegans

 
 
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High impact information on ark-1

  • A screen for synthetic enhancers of sli-1 identified ark-1 (forAck-related tyrosine kinase), a novel inhibitor of let-23 EGFR signaling in C. elegans [1].
  • An ark-1 mutation synergizes with mutations in other negative regulators of let-23, resulting in increased RAS signaling [1].
  • Further, we identify an inhibitory tyrosine of LET-23 requiring sli-1(+) for its effects: removal of this tyrosine closely mimics the loss of sli-1 but not of another negative regulator, ark-1 [2].

References

  1. ARK-1 inhibits EGFR signaling in C. elegans. Hopper, N.A., Lee, J., Sternberg, P.W. Mol. Cell (2000) [Pubmed]
  2. Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Yoon, C.H., Chang, C., Hopper, N.A., Lesa, G.M., Sternberg, P.W. Mol. Biol. Cell (2000) [Pubmed]
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