The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

let-23  -  Protein LET-23

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on let-23


Biological context of let-23

  • The sli-1 locus displays dosage sensitivity: severe reduction of function alleles of sli-1 are semidominant suppressors; a duplication of the sli-1(+) region enhances the vulvaless phenotype of hypomorphic mutations of let-23 [5].
  • Our genetic epistasis experiments suggest that sli-3 functions either downstream or in parallel to nuclear factors lin-1 and sur-2. sli-3 synergistically interacts with the previously identified negative regulators of the let-23 signaling pathway and causes excessive cell proliferation [6].
  • In Caenorhabditis elegans, the vulval induction is mediated by tyrosine kinase receptor/Ras signal transduction pathway composed of the lin-3, let-23, and let-60 products [7].
  • We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1 [8].
  • The penetrance of the multivulva phenotype caused by loss-of-function mutations in lin-15, and gain-of-function mutations in let-23 or let-60 ras, was reduced by ptp-2(op194) [9].

Anatomical context of let-23

  • The let-60 gene of Caenorhabditis elegans controls the choice between vulval and hypodermal differentiation in response to an inductive signal from the gonad. let-60 encodes a ras protein that acts downstream of the let-23 receptor tyrosine kinase in a signal transduction pathway [10].

Physical interactions of let-23

  • The product of C. elegans lin-7 directly interacts with let-23 RTK and localize it at epithelial junctions [11].

Other interactions of let-23

  • A second extracellular cue, from Y.p, also acts antagonistically to the lin-3/let-23 pathway [12].
  • Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase [13].
  • Reduction-of-function mutations in two Caenorhabditis elegans genes, the receptor tyrosine kinase gene let-23 and the collagen gene dpy-10, both alter the AG at the end of a short (ca. 50-nucleotide) intron to AA [14].
  • The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP(3) signaling in the adult spermatheca. ipp-5 acts downstream of let-23, and interacts with let-23-mediated IP(3) signaling pathway genes [15].
  • The precise localization of the let-23 RTK at the epithelial junctions is essential for the vulval induction, and requires three genes including lin-2, -7, and -10 [11].

Analytical, diagnostic and therapeutic context of let-23


  1. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Kaech, S.M., Whitfield, C.W., Kim, S.K. Cell (1998) [Pubmed]
  2. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Tan, P.B., Lackner, M.R., Kim, S.K. Cell (1998) [Pubmed]
  3. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Clark, S.G., Stern, M.J., Horvitz, H.R. Nature (1992) [Pubmed]
  4. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Aroian, R.V., Koga, M., Mendel, J.E., Ohshima, Y., Sternberg, P.W. Nature (1990) [Pubmed]
  5. sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Jongeward, G.D., Clandinin, T.R., Sternberg, P.W. Genetics (1995) [Pubmed]
  6. sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans. Gupta, B.P., Liu, J., Hwang, B.J., Moghal, N., Sternberg, P.W. Genetics (2006) [Pubmed]
  7. Molecular cloning and characterization of rat lin-10. Ide, N., Hirao, K., Hata, Y., Takeuchi, M., Irie, M., Yao, I., Deguchi, M., Toyoda, A., Nishioka, H., Mizoguchi, A., Takai, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. ARK-1 inhibits EGFR signaling in C. elegans. Hopper, N.A., Lee, J., Sternberg, P.W. Mol. Cell (2000) [Pubmed]
  9. The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Gutch, M.J., Flint, A.J., Keller, J., Tonks, N.K., Hengartner, M.O. Genes Dev. (1998) [Pubmed]
  10. Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene. Han, M., Sternberg, P.W. Genes Dev. (1991) [Pubmed]
  11. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Irie, M., Hata, Y., Deguchi, M., Ide, N., Hirao, K., Yao, I., Nishioka, H., Takai, Y. Oncogene (1999) [Pubmed]
  12. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Chamberlin, H.M., Sternberg, P.W. Development (1994) [Pubmed]
  13. Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Hajnal, A., Whitfield, C.W., Kim, S.K. Genes Dev. (1997) [Pubmed]
  14. Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site. Aroian, R.V., Levy, A.D., Koga, M., Ohshima, Y., Kramer, J.M., Sternberg, P.W. Mol. Cell. Biol. (1993) [Pubmed]
  15. Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation. Bui, Y.K., Sternberg, P.W. Mol. Biol. Cell (2002) [Pubmed]
  16. Genomic structure and 5' regulatory regions of the let-23 gene in the nematode C. elegans. Sakai, T., Koga, M., Ohshima, Y. J. Mol. Biol. (1996) [Pubmed]
WikiGenes - Universities