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Gene Review:

fat-2 - Protein FAT-2

Caenorhabditis elegans

Peyou-Ndi, M.M. et al., Ge, Y. et al.

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Disease relevance of fat-2

Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells [1].

High impact information on fat-2

In addition, it conforms to the structural constraints expected of a membrane-bound fatty acid desaturase including the canonical histidine-rich regions [2].
The predicted protein is highly homologous both to the cloned plant genes with similar function and to the published sequence of the C. elegans omega-3 fatty acid desaturase [2].

References

Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Ge, Y., Chen, Z., Kang, Z.B., Cluette-Brown, J., Laposata, M., Kang, J.X. Anticancer Res. (2002) [Pubmed]
Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Peyou-Ndi, M.M., Watts, J.L., Browse, J. Arch. Biochem. Biophys. (2000) [Pubmed]

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