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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-1  -  Protein UNC-1

Caenorhabditis elegans

 
 
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High impact information on unc-1

  • Whereas unc-1 is expressed in the majority of neurons of C. elegans, expression of SSU-1 protein in only the two ASJ amphid interneurons is sufficient to restore the wild type phenotype [1].
  • We examined the interaction of multiple alleles of unc-1 and unc-8 with each other and with other genes affecting anesthetic sensitivity [2].
  • The protein UNC-1 is a close homologue of the mammalian protein stomatin [2].
  • Because different unc-1 alleles cause strikingly different phenotypes in different volatile anesthetics, the UNC-1 protein is a candidate to directly interact with volatile anesthetics [3].

References

  1. Sulfated Signal from ASJ Sensory Neurons Modulates Stomatin-dependent Coordination in Caenorhabditis elegans. Carroll, B.T., Dubyak, G.R., Sedensky, M.M., Morgan, P.G. J. Biol. Chem. (2006) [Pubmed]
  2. A stomatin and a degenerin interact to control anesthetic sensitivity in Caenorhabditis elegans. Rajaram, S., Spangler, T.L., Sedensky, M.M., Morgan, P.G. Genetics (1999) [Pubmed]
  3. Tail clamp responses in stomatin knockout mice compared with mobility assays in Caenorhabditis elegans during exposure to diethyl ether, halothane, and isoflurane. Sedensky, M.M., Pujazon, M.A., Morgan, P.G. Anesthesiology (2006) [Pubmed]
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