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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Interneurons

 
 
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Disease relevance of Interneurons

 

Psychiatry related information on Interneurons

 

High impact information on Interneurons

  • Moreover, we found that GRP receptor (GRPR) is expressed in GABAergic interneurons of the lateral nucleus [11].
  • Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 interneuron differentiation [12].
  • These mice also showed aberrant migration and differentiation of interneurons containing gamma-aminobutyric acid (GABAergic interneurons) in the ganglionic eminence and neocortex as well as abnormal testicular differentiation [13].
  • Lhx3 is involved in the generation of two adjacent, but distinct, cell types for locomotion, motor neurons and V2 interneurons [12].
  • Upon Pax6 inactivation, the potential of RPCs becomes entirely restricted to only one of the cell fates normally available to RPCs, resulting in the exclusive generation of amacrine interneurons [14].
 

Chemical compound and disease context of Interneurons

 

Biological context of Interneurons

 

Anatomical context of Interneurons

 

Associations of Interneurons with chemical compounds

  • Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation [30].
  • In lamprey, 5-HT neurons control apamine-sensitive KCa channels in spinal locomotor network interneurons, thereby in addition regulating the duration of locomotor bursts [31].
  • Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus [32].
  • Thus, proctolin is a cardioactive peptide, a skeletal neuromuscular transmitter, a hindgut neuropeptide, a peptide of CNS interneurons (Keshishian & O'Shea 1984) and may have humoral roles [33].
  • Nitric oxide mediates network oscillations of olfactory interneurons in a terrestrial mollusc [34].
 

Gene context of Interneurons

  • A population of interneurons that express Engrailed1 (EN1), however, also fails to differentiate in Isl1 mutant embryos [35].
  • In Gdf7-null mutant embryos, the generation of D1A neurons is eliminated but D1B neurons and other identified dorsal interneurons are unaffected [36].
  • Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord [36].
  • Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy [24].
  • This system of AMPA receptor-dependent synaptic NMDA receptor localization was preserved in hippocampal interneurons but reversed in hippocampal pyramidal neurons [37].
 

Analytical, diagnostic and therapeutic context of Interneurons

References

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