Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ncr-1 - Protein NCR-1

Caenorhabditis elegans

Li, J. et al., Sym, M. et al.

Sym, Basson, Johnson,

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High impact information on ncr-1

Only the ncr-1 mutant is hypersensitive to cholesterol deprivation and to progesterone, an inhibitor of intracellular cholesterol trafficking [1].
Furthermore, npc-1; npc-2 double-mutant animals inappropriately formed dauer larvae under favorable growth conditions [2].

References

NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways. Li, J., Brown, G., Ailion, M., Lee, S., Thomas, J.H. Development (2004) [Pubmed]
A model for niemann-pick type C disease in the nematode Caenorhabditis elegans. Sym, M., Basson, M., Johnson, C. Curr. Biol. (2000) [Pubmed]

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