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Gene Review:

unc-27 - Protein UNC-27

Caenorhabditis elegans

Burkeen, A.K. et al., Ruksana, R. et al.

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High impact information on unc-27

Experiments revealed that unc-27 is one of four C. elegans troponin I genes and that three mutant alleles truncate the protein: recessive and presumed null allele e155 terminates after nine codons; semidominant su142sd eliminates the inhibitory and C-terminal regions; and semidominant su195sd abbreviates the extreme C-terminus [1].
Expressing tni-1 and -2 gene RNAi caused motility defects similar to unc-27 (e155) mutant, a tni-2 null allele [2].

References

Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I. Burkeen, A.K., Maday, S.L., Rybicka, K.K., Sulcove, J.A., Ward, J., Huang, M.M., Barstead, R., Franzini-Armstrong, C., Allen, T.S. Biophys. J. (2004) [Pubmed]
Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana, R., Kuroda, K., Terami, H., Bando, T., Kitaoka, S., Takaya, T., Sakube, Y., Kagawa, H. Genes Cells (2005) [Pubmed]

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