Psychiatry related information on troponin

• C. elegans model for studying tropomyosin and troponin regulations of muscle contraction and animal behavior [1].

High impact information on troponin

• The structural gene for this troponin is pat-10 and mutations in this gene lead to animals that arrest as twofold paralyzed embryos late in development [2].
• We show that contraction of the ovarian muscle requires tropomyosin and troponin, which are generally major actin-linked regulators of contraction of striated muscle [3].
• Molluscs lack actin control since troponin is not present in sufficient quantities [4].
• Experiments revealed that unc-27 is one of four C. elegans troponin I genes and that three mutant alleles truncate the protein: recessive and presumed null allele e155 terminates after nine codons; semidominant su142sd eliminates the inhibitory and C-terminal regions; and semidominant su195sd abbreviates the extreme C-terminus [5].
• To characterize the Caenorhabditis elegans troponin I family, we analyzed gene structures, tissue expression patterns and RNAi phenotypes of four troponin I isoforms [6].

Biological context of troponin

• Further studies on troponin using an antiserum raised to the recombinant protein demonstrated that the protein, unlike the mRNA, was present in all life-cycle stages examined, while immunogold labelling demonstrated that it was localized to the muscle blocks [7].

Anatomical context of troponin

• The increased synthesis of forms of myosin, actin and troponin in the nematode living in the rapid-responder SWR host may relate to the attempted reorganisation or repair of the cytoskeleton and/or muscle layer in the host immune initiated, increased mucus production and smooth muscle activity within intestinal environment [8].

Other interactions of troponin

• The tni-3 RNAi expression produced egg laying defects while the tni-4 RNAi caused arrest at gastrulation [6].

References