Gene Review:
syg-2 - Protein SYG-2
Caenorhabditis elegans
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High impact information on syg-2
- SYG-2 binds SYG-1, the receptor on HSNL, and directs SYG-1 accumulation and synapse formation to adjacent regions of HSNL. syg-1 and syg-2 mutants have defects in synaptic specificity; the HSNL neuron forms fewer synapses onto its normal targets and forms ectopic synapses onto inappropriate targets [1].
References
- Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Shen, K., Fetter, R.D., Bargmann, C.I. Cell (2004) [Pubmed]
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