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Gene Review

hbs  -  hibris

Drosophila melanogaster

Synonyms: CG7449, CT22841, Dmel\CG7449, Hbs, icon
 
 
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High impact information on hbs

  • Among the 83 genes differentially expressed, we found genes known to be enriched in FCs or FCMs, such as heartless or hibris, previously characterized genes with unknown roles in muscle development, and predicted genes of unknown function [1].
  • The two proteins act antagonistically: loss of sns dominantly suppresses the hbs myoblast fusion and visceral mesoderm phenotypes, and enhances Hbs overexpression phenotypes [2].
  • In the somatic mesoderm, Hbs is restricted to fusion competent myoblasts and is regulated by Notch and Ras signaling pathways [2].
  • We propose that the temporal pattern of hbs expression within fusion-competent myoblasts may reflect previously undescribed functional differences within this myoblast population [2].
  • Data from a P-homed enhancer reporter into hbs and co-localization studies with Sns suggest that hbs is not continuously expressed in all fusion-competent myoblasts during the fusion process [2].
 

Biological context of hbs

 

Anatomical context of hbs

 

Associations of hbs with chemical compounds

  • Hibris (Hbs) is a transmembrane immunoglobulin-like protein that shows extensive homology to Drosophila Sticks and stones (Sns) and human kidney protein Nephrin [2].
 

Other interactions of hbs

  • The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling [2].
  • Hibris encodes a protein that is a newly identified member of the immunoglobulin superfamily and has homology to vertebrate Nephrins and Drosophila Sticks-and-Stones [3].
  • We propose that Hibris is an extracellular partner for Dumbfounded and potentially mediates the response of myoblasts to this attractant [3].
  • Primary pigment cells employ Hibris to function as organizers in this process; IPCs minimize contacts with neighboring IPCs and utilize Roughest to maximize contacts with primaries [4].

References

 
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