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Gene Review:

lin-32 - Protein LIN-32

Caenorhabditis elegans

Ross, J.M. et al., Portman, D.S. et al., Portman, D.S. et al., Mitani, S. et al., Du, H. et al.

Portman, Emmons, Portman, Emmons,

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High impact information on lin-32

Mutations in hlh-2, the gene encoding the C. elegans E/daughterless ortholog, enhance the ray defects caused by lin-32 mutations [1].
Previous studies have identified three genes (lin-32, unc-86 and mec-3) that regulate touch cell development [2].
A similar touch cell phenotype is produced by mutations in lin-32 [3].
Here we show that MAB-3 promotes expression of the proneural protein LIN-32 in V ray precursors by transcriptional repression of ref-1, a member of the Hes family of neurogenic factors [4].

Other interactions of lin-32

The atonal ortholog lin-32 and the E/daughterless ortholog hlh-2 act to confer neural competence during ray development, but additional regulatory factors that control specific aspects of cell fate are largely unknown [5].

References

The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Portman, D.S., Emmons, S.W. Development (2000) [Pubmed]
Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Mitani, S., Du, H., Hall, D.H., Driscoll, M., Chalfie, M. Development (1993) [Pubmed]
Genes regulating touch cell development in Caenorhabditis elegans. Du, H., Chalfie, M. Genetics (2001) [Pubmed]
The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Ross, J.M., Kalis, A.K., Murphy, M.W., Zarkower, D. Dev. Cell (2005) [Pubmed]
Identification of C. elegans sensory ray genes using whole-genome expression profiling. Portman, D.S., Emmons, S.W. Dev. Biol. (2004) [Pubmed]

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