Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

srn - siren

Mus musculus

Orr, B.Y. et al., Hoornbeek, F.K. et al.

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Disease relevance of srn

The srn gene responsible for sirenomelia might either directly affect the embryo at both the caudal and cranial regions or indirectly affect the embryo by producing lateral mechanical compression at both these sites [1].

High impact information on srn

Analyses of uterine contents at days 12-14 suggest that the srn gene is fully penetrant, but often lethal, during the fetal period [1].
Variation in the urogenital system was similar to that found in siren pups with the srn/srn genotype [2].

References

Craniofacial, caudal, and visceral anomalies associated with mutant sirenomelic mice. Orr, B.Y., Long, S.Y., Steffek, A.J. Teratology (1982) [Pubmed]
Modification toward dominance of a recessive lethal in the mouse. Hoornbeek, F.K., Adams, M.J. J. Hered. (1975) [Pubmed]

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