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Gene Review

Mmp7  -  matrix metallopeptidase 7

Mus musculus

Synonyms: MAT, MMP-7, Matrilysin, Matrin, Matrix metalloproteinase-7, ...
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Disease relevance of Mmp7


Psychiatry related information on Mmp7

  • As in the case with in vitro tests, results from a single in vivo test, such as a change in uterine weight, should not be used as a basis for regulatory decision making [6].
  • In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estrogen target tissues and results in long-term abnormalities such as uterine neoplasia that are not manifested until later in life [7].
  • Sperm abnormalities were examined in the samples of the uterine contents collected after copulation [8].
  • The masses of the ovaries and uterus, the numbers of developing follicles and corpora lutea, and the development of the uterine wall were all reduced by food deprivation at 26 degrees C to levels similar to those that resulted from a reduction in ambient temperature to 15 degrees C with a reduction in food quantity [9].

High impact information on Mmp7


Chemical compound and disease context of Mmp7


Biological context of Mmp7


Anatomical context of Mmp7


Associations of Mmp7 with chemical compounds

  • The attachment of the blastocyst to the uterine luminal epithelium and the subsequent invasion by trophoblast cells through the stroma and deciduum occur in a highly regulated manner by remodeling of the extracellular matrix [23].
  • This estrogen regulation of MMP-9 activity may play an important role in uterine tissue remodeling [24].
  • Female mice (2-3 months old) were ovariectomized and treated with estradiol-l7beta (E(2)) or E(2) + progesterone (P(4)) and uterine gelatinase activity and expression were determined [24].
  • Pretreatment with a transcription inhibitor actinomycin D or translation inhibitor cycloheximide indicates that E(2) regulates uterine MMP-9 at multiple points, involving transcriptional and posttranscriptional control as well as modulation of inhibitor activities [24].
  • We have observed that in integrin alpha1-null mice synthesis of MMP7 and MMP9 was markedly increased compared with that of their wild-type counterparts [25].

Physical interactions of Mmp7


Enzymatic interactions of Mmp7


Regulatory relationships of Mmp7


Other interactions of Mmp7


Analytical, diagnostic and therapeutic context of Mmp7


  1. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Li, Q., Park, P.W., Wilson, C.L., Parks, W.C. Cell (2002) [Pubmed]
  2. Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Vargo-Gogola, T., Fingleton, B., Crawford, H.C., Matrisian, L.M. Cancer Res. (2002) [Pubmed]
  3. Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice. Powell, W.C., Knox, J.D., Navre, M., Grogan, T.M., Kittelson, J., Nagle, R.B., Bowden, G.T. Cancer Res. (1993) [Pubmed]
  4. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. Chavey, C., Mari, B., Monthouel, M.N., Bonnafous, S., Anglard, P., Van Obberghen, E., Tartare-Deckert, S. J. Biol. Chem. (2003) [Pubmed]
  5. Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model. Kioi, M., Yamamoto, K., Higashi, S., Koshikawa, N., Fujita, K., Miyazaki, K. Oncogene (2003) [Pubmed]
  6. Adequacy of required regulatory hazard testing for the detection of potential hormonal activity of crop protection chemicals. Stevens, J.T., Gfeller, W., Machemer, L., Leist, K.H. Journal of toxicology and environmental health. Part B, Critical reviews. (1998) [Pubmed]
  7. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Newbold, R.R., Padilla-Banks, E., Jefferson, W.N. Endocrinology (2006) [Pubmed]
  8. Sperm head abnormalities in relation to the age and strain of mice. Krzanowska, H. J. Reprod. Fertil. (1981) [Pubmed]
  9. Gender differences in the inhibitory effects of a reduction in ambient temperature and a reduction in food quantity on reproduction in the Southern African rodent, Rhabdomys pumilio. Jackson, C., Bernard, R.T. Reproduction (2001) [Pubmed]
  10. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  11. Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha. Horton, E.W., Poyser, N.L. Physiol. Rev. (1976) [Pubmed]
  12. Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Lee, K., Jeong, J., Kwak, I., Yu, C.T., Lanske, B., Soegiarto, D.W., Toftgard, R., Tsai, M.J., Tsai, S., Lydon, J.P., Demayo, F.J. Nat. Genet. (2006) [Pubmed]
  13. Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Surendran, K., Simon, T.C., Liapis, H., McGuire, J.K. Kidney Int. (2004) [Pubmed]
  14. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Zuo, F., Kaminski, N., Eugui, E., Allard, J., Yakhini, Z., Ben-Dor, A., Lollini, L., Morris, D., Kim, Y., DeLustro, B., Sheppard, D., Pardo, A., Selman, M., Heller, R.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice. Nothnick, W.B., Zhang, X., Zhou, H.E. Biol. Reprod. (2004) [Pubmed]
  16. Role of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour. Olson, D.M., Ammann, C. Front. Biosci. (2007) [Pubmed]
  17. Binding of alpha5 monoclonal antibody to cell surface alpha5beta1 integrin modulates MMP-2 and MMP-7 activity in B16F10 melanoma cells. Mitra, A., Chakrabarti, J., Chatterjee, A. J. Environ. Pathol. Toxicol. Oncol. (2003) [Pubmed]
  18. Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice. Kelley, R.L., Kind, K.L., Lane, M., Robker, R.L., Thompson, J.G., Edwards, L.J. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  19. Role of sympathetic nerves on early embryonic development and immune modulation of uterus in pregnant mice. Dong, Y., Chen, Y., Wang, Z., Naito, J., Chen, J.L. Autonomic neuroscience : basic & clinical (2007) [Pubmed]
  20. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Yu, W.H., Woessner, J.F., McNeish, J.D., Stamenkovic, I. Genes Dev. (2002) [Pubmed]
  21. Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. Brenner, C.A., Adler, R.R., Rappolee, D.A., Pedersen, R.A., Werb, Z. Genes Dev. (1989) [Pubmed]
  22. Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice. Rudolph-Owen, L.A., Hulboy, D.L., Wilson, C.L., Mudgett, J., Matrisian, L.M. Endocrinology (1997) [Pubmed]
  23. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. Das, S.K., Yano, S., Wang, J., Edwards, D.R., Nagase, H., Dey, S.K. Dev. Genet. (1997) [Pubmed]
  24. Regulation of MMP-9 expression and activity in the mouse uterus by estrogen. Zhang, X., Christenson, L.K., Nothnick, W.B. Mol. Reprod. Dev. (2007) [Pubmed]
  25. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Pozzi, A., Moberg, P.E., Miles, L.A., Wagner, S., Soloway, P., Gardner, H.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  26. Cannabinoid ligand-receptor signaling in the mouse uterus. Das, S.K., Paria, B.C., Chakraborty, I., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo. Klaffky, E., Williams, R., Yao, C.C., Ziober, B., Kramer, R., Sutherland, A. Dev. Biol. (2001) [Pubmed]
  28. Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissue. Stagg, A.J., Tuffrey, M., Woods, C., Wunderink, E., Knight, S.C. Infect. Immun. (1998) [Pubmed]
  29. Effect of chaotropic anions on the rate of dissociation of estradiol-receptor protein complexes of mouse uterine cytosol. Kumar, S.A., Beach, T., Dickerman, H.W. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  30. Histamine H1 receptor binding sites in mouse uterine horns. Gonzalez, R., Reinicke, K., Rudolph, G.M. Gen. Pharmacol. (1993) [Pubmed]
  31. Expression and distribution of osteopontin and matrix metalloproteinase (MMP)-3 and -7 in mouse salivary glands. Muramatsu, T., Ohta, K., Asaka, M., Kizaki, H., Shimono, M. European journal of morphology. (2002) [Pubmed]
  32. Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Lim, H., Ma, L., Ma, W.G., Maas, R.L., Dey, S.K. Mol. Endocrinol. (1999) [Pubmed]
  33. Disruption of the tissue inhibitor of metalloproteinase-1 gene in reproductive-age female mice is associated with estrous cycle stage-specific increases in stromelysin messenger RNA expression and activity. Nothnick, W.B. Biol. Reprod. (2001) [Pubmed]
  34. Epithelial-mesenchymal interactions in uterus and vagina alter the expression of the cell surface proteoglycan, syndecan. Boutin, E.L., Sanderson, R.D., Bernfield, M., Cunha, G.R. Dev. Biol. (1991) [Pubmed]
  35. A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. Nose, A., Takeichi, M. J. Cell Biol. (1986) [Pubmed]
  36. Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation. White, F.J., Burghardt, R.C., Hu, J., Joyce, M.M., Spencer, T.E., Johnson, G.A. Reproduction (2006) [Pubmed]
  37. Matrix Metalloproteinase (MMP)-7 Activates MMP-8 But Not MMP-13. Dozier, S., Escobar, G.P., Lindsey, M.L. Medicinal chemistry (Sh???ariqah, United Arab Emirates) (2006) [Pubmed]
  38. Role of estrogen receptor beta in uterine stroma and epithelium: Insights from estrogen receptor beta-/- mice. Wada-Hiraike, O., Hiraike, H., Okinaga, H., Imamov, O., Barros, R.P., Morani, A., Omoto, Y., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  39. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Powell, W.C., Fingleton, B., Wilson, C.L., Boothby, M., Matrisian, L.M. Curr. Biol. (1999) [Pubmed]
  40. Melanocyte mediated paracrine induction of extracellular matrix degrading proteases in squamous cell carcinoma cells. Borchers, A.H., Sanders, L.A., Powell, M.B., Bowden, G.T. Exp. Cell Res. (1997) [Pubmed]
  41. Matrilysin expression and function in airway epithelium. Dunsmore, S.E., Saarialho-Kere, U.K., Roby, J.D., Wilson, C.L., Matrisian, L.M., Welgus, H.G., Parks, W.C. J. Clin. Invest. (1998) [Pubmed]
  42. Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle. Suzuki, A., Enari, M., Eguchi, Y., Matsuzawa, A., Nagata, S., Tsujimoto, Y., Iguchi, T. EMBO J. (1996) [Pubmed]
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