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Gene Review

EVI2B  -  ecotropic viral integration site 2B

Homo sapiens

Synonyms: CD361, D17S376, EVDB, EVI-2B, Ecotropic viral integration site 2B protein homolog, ...
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Disease relevance of EVI2B

  • Here, the amounts of NF1 and EVI2B mRNA were investigated in detail in cells involved in NF1 manifestations as café-au-lait macules and neurofibromas [1].
  • The EVI2B gene is one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1; M. Recklinghausen) gene, which are transcribed in the direction opposite that of the NF1 gene [1].

High impact information on EVI2B

  • Minimally, each of the deletions involved the entire 350-kb NF1 gene; the three genes--EVI2A, EVI2B, and OMG--that are contained within an NF1 intron; and considerable flanking DNA [2].
  • Whereas in NF1 melanocytes from café-au-lait macules, EVI2B expression was not altered, in fibroblast-like cells derived from neurofibromas, an increased level of EVI2B mRNA was found [1].
  • These investigations showed that aside from the NF1 gene, EVI2B is involved in melanocyte and keratinocyte differentiation [1].

Biological context of EVI2B


  1. EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. Kaufmann, D., Gruener, S., Braun, F., Stark, M., Griesser, J., Hoffmeyer, S., Bartelt, B. DNA Cell Biol. (1999) [Pubmed]
  2. Deletions spanning the neurofibromatosis 1 gene: identification and phenotype of five patients. Kayes, L.M., Burke, W., Riccardi, V.M., Bennett, R., Ehrlich, P., Rubenstein, A., Stephens, K. Am. J. Hum. Genet. (1994) [Pubmed]
  3. A polymorphic cDNA probe on chromosome 17q11.2 located within the NF1 gene [D17S376]. Andersen, L.B., Wallace, M.R., Marchuk, D.A., Cawthon, R.M., Odeh, H.M., Letcher, R., White, R.L., Collins, F.S. Nucleic Acids Res. (1991) [Pubmed]
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