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Gene Review:

tct1 - t complex tail interaction 1

Mus musculus

Synonyms: tct, tct-1

Justice, M.J. et al., Rennebeck, G. et al., Artzt, K. et al., Ruvinsky, A. et al., Nadeau, J.H. et al.

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High impact information on tct1

Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor [1].
It is suggested that the gene dosage ratio at the tir and tct loci determines tail length [2].
Genetic evidence for two t complex tail interaction (tct) loci in t haplotypes [3].
It is unlinked to the T/t-complex on chromosome 17 and yet it shows cumulative phenotypic effects with several t-complex mutations: T, TCu, tct and Fuki [4].
Like the original brachyury (T) mutation, the new alleles cause a short-tailed phenotype in heterozygotes, and interact with the t complex tail interaction factor (tct) in trans to cause phenotypically tailless mice [5].

References

Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct. Rennebeck, G., Lader, E., Fujimoto, A., Lei, E.P., Artzt, K. Genetics (1998) [Pubmed]
Functional analysis of mutations of murine chromosome 17 with the use of tertiary trisomy. Ruvinsky, A., Agulnik, A., Agulnik, S., Rogachova, M. Genetics (1991) [Pubmed]
Genetic evidence for two t complex tail interaction (tct) loci in t haplotypes. Nadeau, J.H., Varnum, D., Burkart, D. Genetics (1989) [Pubmed]
A new mutation (t-int) interacts with the mutations of the mouse T/t complex that affect the tail. Artzt, K., Cookingham, J., Bennett, D. Genetics (1987) [Pubmed]
ENU-induced allele of brachyury (Tkt1) exhibits a developmental lethal phenotype similar to the original brachyury (T) mutation. Justice, M.J., Bode, V.C. J. Exp. Zool. (1990) [Pubmed]

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