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Gene Review

Lin7c  -  lin-7 homolog C (C. elegans)

Mus musculus

Synonyms: 9130007B12Rik, AI303698, AU019331, AW125731, D2Ertd520e, ...
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High impact information on Lin7c

  • At the OPL, Mpp4 is essential for correct localization of Psd95 and Veli3 at the presynaptic photoreceptor membrane [1].
  • Interestingly, MALS-3 protein is dramatically induced in the MALS-1/2 double knockouts, implying that dynamic changes in protein expression may play an important regulatory role for this family of synaptic PDZ proteins [2].


  1. Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Aartsen, W.M., Kantardzhieva, A., Klooster, J., van Rossum, A.G., van de Pavert, S.A., Versteeg, I., Cardozo, B.N., Tonagel, F., Beck, S.C., Tanimoto, N., Seeliger, M.W., Wijnholds, J. Hum. Mol. Genet. (2006) [Pubmed]
  2. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. Misawa, H., Kawasaki, Y., Mellor, J., Sweeney, N., Jo, K., Nicoll, R.A., Bredt, D.S. J. Biol. Chem. (2001) [Pubmed]
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