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ELL2  -  elongation factor, RNA polymerase II, 2

Homo sapiens

Synonyms: RNA polymerase II elongation factor ELL2
 
 
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High impact information on ELL2

  • Structure-function studies localize the ELL2 elongation activation domain to an ELL2 N-terminal region that is highly homologous to ELL [1].
  • In addition, endogenous EAF1 also exhibited the capacity to interact with ELL2 [2].
  • Here we identify multiple transcriptional elongation factors, including ELL2, TFIIF(1), TFIIS, and FACT, as PITSLRE kinase-associated proteins [3].
  • Upregulation of ELL2 in plasma cells shifts expression of the Igh gene towards the secretory specific form by favoring the selection of the promoter proximal poly(A) site. ELL2 facilitates binding of CstF-64 (CstF2) to the RNA Pol II [4].
 

Other interactions of ELL2

  • Mechanistic studies indicate that ELL2 and ELL possess similar transcriptional activities [1].

References

  1. ELL2, a new member of an ELL family of RNA polymerase II elongation factors. Shilatifard, A., Duan, D.R., Haque, D., Florence, C., Schubach, W.H., Conaway, J.W., Conaway, R.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. Simone, F., Polak, P.E., Kaberlein, J.J., Luo, R.T., Levitan, D.A., Thirman, M.J. Blood (2001) [Pubmed]
  3. PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. Trembley, J.H., Hu, D., Hsu, L.C., Yeung, C.Y., Slaughter, C., Lahti, J.M., Kidd, V.J. J. Biol. Chem. (2002) [Pubmed]
  4. Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Martincic, K., Alkan, S.A., Cheatle, A., Borghesi, L., Milcarek, C. Nat. Immunol. (2009) [Pubmed]
 
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