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Gene Review

EAF1  -  ELL associated factor 1

Homo sapiens

Synonyms: ELL-associated factor 1
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High impact information on EAF1

  • EAF2 is highly homologous to EAF1, with 58% identity and 74% amino acid conservation [1].
  • In contrast to EAF1, EAF2 does not bind to the carboxy-terminus of ELL [1].
  • ELL is an RNA polymerase II elongation factor that interacts with the recently identified EAF1 protein [1].
  • In addition, endogenous EAF1 also exhibited the capacity to interact with ELL2 [2].
  • Transfection of the MLL-ELL fusion gene delocalized EAF1 from its nuclear speckled distribution to a diffuse nucleoplasmic pattern [2].

Biological context of EAF1


Anatomical context of EAF1


Associations of EAF1 with chemical compounds

  • Resistance to AF was also demonstrated in another substrain (HE100) originally selected for by its cadmium resistance, and characterized by a high cytosolic metallothionein (MT) content [3].

Other interactions of EAF1


  1. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Simone, F., Luo, R.T., Polak, P.E., Kaberlein, J.J., Thirman, M.J. Blood (2003) [Pubmed]
  2. EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. Simone, F., Polak, P.E., Kaberlein, J.J., Luo, R.T., Levitan, D.A., Thirman, M.J. Blood (2001) [Pubmed]
  3. Acquired resistance to auranofin in cultured human cells. Glennås, A., Rugstad, H.E. Scand. J. Rheumatol. (1985) [Pubmed]
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