Gene Review:
ABCF1
-
ATP-binding cassette, sub-family F (GCN20)...
Homo sapiens
Synonyms:
ABC27, ABC50, ATP-binding cassette 50, ATP-binding cassette sub-family F member 1, EST123147, ...
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High impact information on ABCF1
- Unlike the majority of ABC proteins, which are membrane-associated transporters, ABC50 associates with the ribosome and co-sediments in sucrose gradients with the 40 and 60 S ribosomal subunits [1].
- ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner [1].
- The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions [2].
- In this manuscript, sequence analysis has been employed to analyse two families of twin-NBD proteins, ABCE and ABCF [3].
Biological context of ABCF1
PMID: 18288386
- ABCF1 is a target of caspase 8 + 10.
PMID: 15013441
- contains pair of nucleotide binding domains (NBD) with no associated transmembrane domains sequence similarity between.
- eukaryotic ABCF proteins, which are involved in translation initiation and elongation .
- prokaryotic ABCF proteins which are implicated in resistance to macrolide inhibitors of protein synthesis .
Re: Interacts with Eukaryotic initiation factor 2 (eIF2 ); PMID: 17894550807
- Regulatory phosphorylation by CK2
- Ser 109, 140; PO4- not required for binding to eIF2
PMID: 9790762
- 2 ABC transporter family signature motifs,
- 2 ATP/GTP-binding site A motifs,
- 3 nuclear localization patterns
- hypothesized that ABC50 and MHC class I are part of the same chromatin expression domain.
- TNF-alpha stimulation increases the expression
PMID: 17964270
- Intron 13 contains the microRNA MIRN877
PMID: 10931828
- Interacts with eiF2
- Associates with ribosome in an ATP-dependent manner
- 110 kDa size protein
- no effect on ability of eIF2 to bind GDP
- markedly enhanced association of methionyl-tRNA
- associates with Ribosome
- co-sediments in sucrose gradients with 40S & 60S ribosomal subunits .
- ATP increases association with ribosome
- ADP increases association with ribosome? mRNA translation control
PMID: 12023305
- protein kinase GCN2 is activated in amino acid-starved cells on binding of uncharged tRNA to a histidyl-tRNA synthetase (HisRS)-related domain
- requirement for ribosome binding, dimerization, and association with the GCN1/GCN20 regulatory complex ...
- suggest that all of these functions facilitate tRNA binding to wild-type GCN2
Sequence:
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKE
QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGK
KTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKA
KPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVS
QAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHI
ANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAER
LEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTL
LMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNY
MTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE
ESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRIC
IVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNL
PYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA
LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE
Ref: <http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id= 69354671log$=ProtAccnMenu>
References
