The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ABCE1  -  ATP-binding cassette, sub-family E (OABP),...

Homo sapiens

Synonyms: 2'-5'-oligoadenylate-binding protein, ABC38, ATP-binding cassette sub-family E member 1, HuHP68, OABP, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ABCE1


High impact information on ABCE1


Biological context of ABCE1


Anatomical context of ABCE1


Associations of ABCE1 with chemical compounds

  • Intramolecular amidofuran cycloadditions across an indole pi-bond: an efficient approach to the aspidosperma and strychnos ABCE core [12].
  • Lysine labeling with NHS-biotin and cross-linking with DTSSP revealed that the 35 amino acid RLI motif at the N terminus is solvent exposed [13].
  • Mutagenesis of the cysteine at position 6 yielded a functional ABCE1 with the ferredoxin-like Fe-S cluster in a paramagnetic [3Fe-4S](+) state [14].

Physical interactions of ABCE1

  • Likewise RLI is coimmunoprecipitated with the RNase L complex by a nuclease-specific antibody [3].

Other interactions of ABCE1


Analytical, diagnostic and therapeutic context of ABCE1

  • These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients [1].
  • In contrast, reduction of RLI levels in RLI antisense cDNA-expressing clones reverses the inhibition of RNase L activity associated with HIV multiplication and leads to a threefold decrease in the viral load [4].
  • Quantitative Competitive PCR (Q/C PCR) analysis showed a statistically significant decrease in RLI mRNA present in the peripheral blood lymphocytes (PBL) of patients with CFIDS (n = 25, mean = 569, S.E = 154) as compared to RLI mRNA level present in peripheral blood lymphocytes (PBL) of healthy controls (n = 15, mean = 2296, S.E = 506; p < 0.0001) [17].
  • Quantitative RT-PCR measurements of RNA from different PBL cell types separated by fluorescence activated cell sorting (FACS) showed that complete RNASEL mRNA levels were significantly elevated in granulocytes compared with all other PBL cell types, whereas expression was lowest in CD8(+) T cells [19].
  • Esophageal pressure amplitude (DeltaPes), inspiratory pulmonary resistance (RLI) and inspiratory flow limitation score (FS) are used as indices of upper airway obstruction for the titration of nasal continuous positive airway pressure (nCPAP) in patients with obstructive sleep apnea syndrome (OSAS) [20].


  1. ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. Shichijo, S., Ishihara, Y., Azuma, K., Komatsu, N., Higashimoto, N., Ito, M., Nakamura, T., Ueno, T., Harada, M., Itoh, K. Oncol. Rep. (2005) [Pubmed]
  2. RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells. Martinand, C., Salehzada, T., Silhol, M., Lebleu, B., Bisbal, C. Eur. J. Biochem. (1998) [Pubmed]
  3. Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. Bisbal, C., Martinand, C., Silhol, M., Lebleu, B., Salehzada, T. J. Biol. Chem. (1995) [Pubmed]
  4. RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. Martinand, C., Montavon, C., Salehzada, T., Silhol, M., Lebleu, B., Bisbal, C. J. Virol. (1999) [Pubmed]
  5. Identification of a host protein essential for assembly of immature HIV-1 capsids. Zimmerman, C., Klein, K.C., Kiser, P.K., Singh, A.R., Firestein, B.L., Riba, S.C., Lingappa, J.R. Nature (2002) [Pubmed]
  6. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. Rökman, A., Ikonen, T., Seppälä, E.H., Nupponen, N., Autio, V., Mononen, N., Bailey-Wilson, J., Trent, J., Carpten, J., Matikainen, M.P., Koivisto, P.A., Tammela, T.L., Kallioniemi, O.P., Schleutker, J. Am. J. Hum. Genet. (2002) [Pubmed]
  7. HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand. Malathi, K., Paranjape, J.M., Ganapathi, R., Silverman, R.H. Cancer Res. (2004) [Pubmed]
  8. Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C. Yu, S.H., Nagayama, K., Enomoto, N., Izumi, N., Marumo, F., Sato, C. Hepatology (2000) [Pubmed]
  9. Chromosomal localization and expression pattern of the RNase L inhibitor gene. Aubry, F., Mattéi, M.G., Barque, J.P., Galibert, F. FEBS Lett. (1996) [Pubmed]
  10. The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. Chen, Z.Q., Dong, J., Ishimura, A., Daar, I., Hinnebusch, A.G., Dean, M. J. Biol. Chem. (2006) [Pubmed]
  11. The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. Le Roy, F., Bisbal, C., Silhol, M., Martinand, C., Lebleu, B., Salehzada, T. J. Biol. Chem. (2001) [Pubmed]
  12. Intramolecular amidofuran cycloadditions across an indole pi-bond: an efficient approach to the aspidosperma and strychnos ABCE core. Lynch, S.M., Bur, S.K., Padwa, A. Org. Lett. (2002) [Pubmed]
  13. Deciphering structure and topology of conserved COG2042 orphan proteins. Armengaud, J., Dedieu, A., Solques, O., Pellequer, J.L., Quemeneur, E. BMC Struct. Biol. (2005) [Pubmed]
  14. Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. Barthelme, D., Scheele, U., Dinkelaker, S., Janoschka, A., Macmillan, F., Albers, S.V., Driessen, A.J., Stagni, M.S., Bill, E., Meyer-Klaucke, W., Schünemann, V., Tampé, R. J. Biol. Chem. (2007) [Pubmed]
  15. Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition. Kerr, I.D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  16. X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly. Karcher, A., Büttner, K., Märtens, B., Jansen, R.P., Hopfner, K.P. Structure (Camb.) (2005) [Pubmed]
  17. Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome. Vojdani, A., Choppa, P.C., Lapp, C.W. Journal of clinical & laboratory immunology. (1998) [Pubmed]
  18. Differential expression of mRNA in human thyroid cells depleted of mitochondrial DNA by ethidium bromide treatment. Thomas, A.W., Majid, A., Sherratt, E.J., Gagg, J.W., Alcolado, J.C. Clin. Sci. (1999) [Pubmed]
  19. An Alternative Spliced RNASEL Variant in Peripheral Blood Leukocytes. Rennert, H., Sadowl, C., Edwards, J., Bantly, D., Molinaro, R.J., Orr-Urtreger, A., Bagg, A., Moore, J.S., Silverman, R.H. J. Interferon Cytokine Res. (2006) [Pubmed]
  20. Respiratory resistive impedance as an index of airway obstruction during nasal continuous positive airway pressure titration. Lorino, A.M., Lofaso, F., Duizabo, D., Zerah, F., Goldenberg, F., d'Ortho, M.P., Harf, A., Lorino, H. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
WikiGenes - Universities