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Gene Review

HECW1  -  HECT, C2 and WW domain containing E3...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase HECW1, HECT, C2 and WW domain-containing protein 1, KIAA0322, NEDD4-like E3 ubiquitin-protein ligase 1, NEDL1, ...
 
 
 
 
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High impact information on HECW1

  • We have more closely defined the role of other amino acids in this region by generating modified proteins in which arginine 7 was replaced with lysine (R7K), aspartate 9 was replaced with arginine (D9R), glycine was substituted for proline 12 (P12G), amino acids 6 to 13 were deleted (delta 613) or the C-terminal KDEL sequence was changed to NEDL [1].

References

  1. Expression and mutagenesis of recombinant cholera toxin A subunit. Vadheim, K.L., Singh, Y., Keith, J.M. Microb. Pathog. (1994) [Pubmed]
 
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