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Gene Review:

CDK19 - cyclin-dependent kinase 19

Homo sapiens

Synonyms: CDC2-related protein kinase 6, CDC2L6, CDK11, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19, ...

Feng, Y. et al., Shi, J. et al., Feng, Y. et al., Shi, J. et al.

Feng, Qi, Martinez, Nelson, Shi, Nelson,

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Disease relevance of CDC2L6

Emerging evidence suggests that CDK11 (cyclin-dependent kinase 11) plays a role in apoptosis and melanoma development [1].

High impact information on CDC2L6

However, substrates of CDK11 during apoptosis have not been identified [2].
Cyclin-dependent kinase 11 (CDK11; also named PITSLRE) is part of the large family of p34(cdc2)-related kinases whose functions appear to be linked with cell cycle progression, tumorigenesis, and apoptotic signaling [2].
The cyclin-dependent kinase 11 interacts with NOT2 [3].
Collectively, these results suggest that CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis [4].
Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria [1].

Biological context of CDC2L6

Interestingly, 14-3-3 gamma shows strong interaction with N-terminal portion of caspase-cleaved CDK11(p110) (CDK11(p60)) product at 48 h after Fas treatment, which correlates with the maximal cleavage level of CDK11(p110) and the maximum activation level of CDK11 kinase activity during apoptosis [4].

Other interactions of CDC2L6

The caspase-processed cyclin-dependent kinase 11 (formerly known as PITSLRE) is implicated in apoptotic signaling [3].

References

Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria. Feng, Y., Ariza, M.E., Goulet, A.C., Shi, J., Nelson, M.A. Biochem. J. (2005) [Pubmed]
The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. Shi, J., Feng, Y., Goulet, A.C., Vaillancourt, R.R., Sachs, N.A., Hershey, J.W., Nelson, M.A. J. Biol. Chem. (2003) [Pubmed]
The cyclin-dependent kinase 11 interacts with NOT2. Shi, J., Nelson, M.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
The cyclin-dependent kinase 11 interacts with 14-3-3 proteins. Feng, Y., Qi, W., Martinez, J., Nelson, M.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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CDKE;1	Arabidopsis thaliana
CDK19	Bos taurus
CDK19	Canis lupus familiaris
cdk19	Danio rerio
CDK19	Gallus gallus
Cdk19	Mus musculus
Os10g0580300	Oryza sativa Japonica Group
CDK19	Pan troglodytes
Cdk19	Rattus norvegicus
cdk19	Xenopus (Silurana) tropicalis

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