The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Mitochondria

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Mitochondria

 

Psychiatry related information on Mitochondria

 

High impact information on Mitochondria

  • The amplitude and dynamics of the Ca(2+) signal are shaped by several mechanisms, including K(+) channels and membrane potential, slow modulation of the plasma membrane Ca(2+)-ATPase, and mitochondria that buffer Ca(2+) and prevent the inactivation of CRAC channels [11].
  • Passive lymphokine withdrawal death may result from the cytoplasmic activation of caspases that is regulated by mitochondria and the Bcl-2 protein [12].
  • DNA polymerase (pol) gamma is the sole DNA polymerase in animal mitochondria [13].
  • Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA subunit and protein subunits, although the composition of the enzyme in mitochondria and chloroplasts is still under debate [14].
  • The role of the various lipid-binding proteins in transmembrane and cytosolic transport of lipids is considered as well as regulation of lipid entry into the mitochondria, focusing on the putative role of AMP-activated protein kinase (AMPK), acetyl CoA carboxylase (ACC), and carnitine during exercise [15].
 

Chemical compound and disease context of Mitochondria

 

Biological context of Mitochondria

 

Anatomical context of Mitochondria

 

Associations of Mitochondria with chemical compounds

 

Gene context of Mitochondria

 

Analytical, diagnostic and therapeutic context of Mitochondria

References

  1. YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism. Caplan, A.J., Cyr, D.M., Douglas, M.G. Cell (1992) [Pubmed]
  2. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Spelbrink, J.N., Li, F.Y., Tiranti, V., Nikali, K., Yuan, Q.P., Tariq, M., Wanrooij, S., Garrido, N., Comi, G., Morandi, L., Santoro, L., Toscano, A., Fabrizi, G.M., Somer, H., Croxen, R., Beeson, D., Poulton, J., Suomalainen, A., Jacobs, H.T., Zeviani, M., Larsson, C. Nat. Genet. (2001) [Pubmed]
  3. Decreased uptake and retention of rhodamine 123 by mitochondria in feline sarcoma virus-transformed mink cells. Johnson, L.V., Summerhayes, I.C., Chen, L.B. Cell (1982) [Pubmed]
  4. Protein biosynthesis in organelles requires misaminoacylation of tRNA. Schön, A., Kannangara, C.G., Gough, S., Söll, D. Nature (1988) [Pubmed]
  5. Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Hwang, P.M., Bunz, F., Yu, J., Rago, C., Chan, T.A., Murphy, M.P., Kelso, G.F., Smith, R.A., Kinzler, K.W., Vogelstein, B. Nat. Med. (2001) [Pubmed]
  6. Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide. Venkatraman, A., Shiva, S., Davis, A.J., Bailey, S.M., Brookes, P.S., Darley-Usmar, V.M. Hepatology (2003) [Pubmed]
  7. Electron transport chain defects in Alzheimer's disease brain. Parker, W.D., Parks, J., Filley, C.M., Kleinschmidt-DeMasters, B.K. Neurology (1994) [Pubmed]
  8. The local control of cytosolic Ca2+ as a propagator of CNS communication--integration of mitochondrial transport mechanisms and cellular responses. Simpson, P.B. J. Bioenerg. Biomembr. (2000) [Pubmed]
  9. In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. Panov, A.V., Burke, J.R., Strittmatter, W.J., Greenamyre, J.T. Arch. Biochem. Biophys. (2003) [Pubmed]
  10. Ultrastructural distribution of glutamate immunoreactivity within neurosecretory endings and pituicytes of the rat neurohypophysis. Meeker, R.B., Swanson, D.J., Greenwood, R.S., Hayward, J.N. Brain Res. (1991) [Pubmed]
  11. Calcium signaling mechanisms in T lymphocytes. Lewis, R.S. Annu. Rev. Immunol. (2001) [Pubmed]
  12. Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Lenardo, M., Chan, K.M., Hornung, F., McFarland, H., Siegel, R., Wang, J., Zheng, L. Annu. Rev. Immunol. (1999) [Pubmed]
  13. DNA polymerase gamma, the mitochondrial replicase. Kaguni, L.S. Annu. Rev. Biochem. (2004) [Pubmed]
  14. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao, S., Scott, F., Fierke, C.A., Engelke, D.R. Annu. Rev. Biochem. (2002) [Pubmed]
  15. Skeletal muscle lipid metabolism in exercise and insulin resistance. Kiens, B. Physiol. Rev. (2006) [Pubmed]
  16. Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfoleded state depends on two chaperonin proteins and Mg-ATP. Goloubinoff, P., Christeller, J.T., Gatenby, A.A., Lorimer, G.H. Nature (1989) [Pubmed]
  17. Salicylate and mitochondrial injury in Reye's syndrome. You, K. Science (1983) [Pubmed]
  18. Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis. Moreadith, R.W., Batshaw, M.L., Ohnishi, T., Kerr, D., Knox, B., Jackson, D., Hruban, R., Olson, J., Reynafarje, B., Lehninger, A.L. J. Clin. Invest. (1984) [Pubmed]
  19. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. Rasmussen, B.B., Holmbäck, U.C., Volpi, E., Morio-Liondore, B., Paddon-Jones, D., Wolfe, R.R. J. Clin. Invest. (2002) [Pubmed]
  20. Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. Miccoli, L., Poirson-Bichat, F., Sureau, F., Bras Gonçalves, R., Bourgeois, Y., Dutrillaux, B., Poupon, M.F., Oudard, S. J. Natl. Cancer Inst. (1998) [Pubmed]
  21. Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. Jungas, R.L., Halperin, M.L., Brosnan, J.T. Physiol. Rev. (1992) [Pubmed]
  22. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Kuwana, T., Mackey, M.R., Perkins, G., Ellisman, M.H., Latterich, M., Schneiter, R., Green, D.R., Newmeyer, D.D. Cell (2002) [Pubmed]
  23. Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons. Shaw, J.M., Feagin, J.E., Stuart, K., Simpson, L. Cell (1988) [Pubmed]
  24. The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12. Royden, C.S., Pirrotta, V., Jan, L.Y. Cell (1987) [Pubmed]
  25. Intron within the large rRNA gene of N. crassa mitochondria: a long open reading frame and a consensus sequence possibly important in splicing. Burke, J.M., RajBhandary, U.L. Cell (1982) [Pubmed]
  26. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Dumont, P., Leu, J.I., Della Pietra, A.C., George, D.L., Murphy, M. Nat. Genet. (2003) [Pubmed]
  27. Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Newmeyer, D.D., Farschon, D.M., Reed, J.C. Cell (1994) [Pubmed]
  28. Subcellular sorting of isoactins: selective association of gamma actin with skeletal muscle mitochondria. Pardo, J.V., Pittenger, M.F., Craig, S.W. Cell (1983) [Pubmed]
  29. RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Liao, X., Butow, R.A. Cell (1993) [Pubmed]
  30. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Spät, A., Hunyady, L. Physiol. Rev. (2004) [Pubmed]
  31. The identification of calmodulin-binding sites on mitochondria in cultured 3T3 cells. Pardue, R.L., Kaetzel, M.A., Hahn, S.H., Brinkley, B.R., Dedman, J.R. Cell (1981) [Pubmed]
  32. Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation. Levenson, R., Macara, I.G., Smith, R.L., Cantley, L., Housman, D. Cell (1982) [Pubmed]
  33. Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. King, M.P., Attardi, G. Cell (1988) [Pubmed]
  34. DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Wong, T.W., Clayton, D.A. Cell (1986) [Pubmed]
  35. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Luo, X., Budihardjo, I., Zou, H., Slaughter, C., Wang, X. Cell (1998) [Pubmed]
  36. Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue. Wilson, R.B., Roof, D.M. Nat. Genet. (1997) [Pubmed]
  37. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Delettre, C., Lenaers, G., Griffoin, J.M., Gigarel, N., Lorenzo, C., Belenguer, P., Pelloquin, L., Grosgeorge, J., Turc-Carel, C., Perret, E., Astarie-Dequeker, C., Lasquellec, L., Arnaud, B., Ducommun, B., Kaplan, J., Hamel, C.P. Nat. Genet. (2000) [Pubmed]
  38. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Casari, G., De Fusco, M., Ciarmatori, S., Zeviani, M., Mora, M., Fernandez, P., De Michele, G., Filla, A., Cocozza, S., Marconi, R., Dürr, A., Fontaine, B., Ballabio, A. Cell (1998) [Pubmed]
  39. Alpha adrenergic-mediated accumulation of calcium in reperfused myocardium. Sharma, A.D., Saffitz, J.E., Lee, B.I., Sobel, B.E., Corr, P.B. J. Clin. Invest. (1983) [Pubmed]
  40. Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis. Olofsson, A.M., Vestberg, M., Herwald, H., Rygaard, J., David, G., Arfors, K.E., Linde, V., Flodgaard, H., Dedio, J., Müller-Esterl, W., Lundgren-Akerlund, E. J. Clin. Invest. (1999) [Pubmed]
  41. Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts. Ambrosio, G., Flaherty, J.T., Duilio, C., Tritto, I., Santoro, G., Elia, P.P., Condorelli, M., Chiariello, M. J. Clin. Invest. (1991) [Pubmed]
  42. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Shirane, M., Nakayama, K.I. Nat. Cell Biol. (2003) [Pubmed]
 
WikiGenes - Universities