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Gene Review

FRMD4B  -  FERM domain containing 4B

Homo sapiens

Synonyms: 6030440G05Rik, FERM domain-containing protein 4B, GRP1-binding protein GRSP1, GRSP1, KIAA1013
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High impact information on FRMD4B

  • Acute translocation and co-localization of GRSP1 and GRP1 to ruffles in the plasma membrane was evident after insulin stimulation [1].

Anatomical context of FRMD4B

  • These results identify GRSP1 as a novel member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling [1].


  1. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. Klarlund, J.K., Holik, J., Chawla, A., Park, J.G., Buxton, J., Czech, M.P. J. Biol. Chem. (2001) [Pubmed]
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