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MeSH Review

Cell Membrane

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Disease relevance of Cell Membrane


Psychiatry related information on Cell Membrane


High impact information on Cell Membrane

  • It is now clear that the plasma membrane does not represent the only platform for Ras/MAPK signaling [11].
  • The pathway by which Golgi-associated Ras becomes activated involves PLCgamma and RasGRP1 and may also require retrograde trafficking of Ras from the plasma membrane to the Golgi as a consequence of depalmitoylation [11].
  • A key organizing element for signaling receptors appears to be cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts [12].
  • The polarized cell expresses the chemokine receptors at the leading cell edge, to which they are conveyed by rafts, a cholesterol-enriched membrane fraction fundamental to the lateral organization of the plasma membrane [13].
  • Investigations into the structure and function of FAAH, in combination with complementary studies of other AS enzymes, have engendered provocative molecular models to explain how this enzyme integrates into cell membranes and terminates fatty acid amide signaling in vivo [14].

Chemical compound and disease context of Cell Membrane


Biological context of Cell Membrane


Anatomical context of Cell Membrane


Associations of Cell Membrane with chemical compounds


Gene context of Cell Membrane

  • Most significant has been the identification of the plasma membrane protein TLR4 as the lipid A signaling receptor of animal cells [33].
  • AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2 [2].
  • The human MDR1 P-glycoprotein (Pgp) extrudes a variety of drugs across the plasma membrane [34].
  • In these mice, Dp71 was localized to the plasma membrane and restored normal levels of dystrophin associated proteins (DAPs), indicating that Dp71 is capable of interacting with the DAPs in a similar manner to dystrophin [35].
  • The Rh antigen is a multi-subunit complex composed of Rh polypeptides and associated glycoproteins (Rh50, CD47, LW and glycophorin B); these interact in the red cell membrane and are lacking or severely reduced in Rhnull cells [36].

Analytical, diagnostic and therapeutic context of Cell Membrane


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  3. Role of the mature protein sequence of maltose-binding protein in its secretion across the E. coli cytoplasmic membrane. Ito, K., Beckwith, J.R. Cell (1981) [Pubmed]
  4. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Wang, D., Liebowitz, D., Kieff, E. Cell (1985) [Pubmed]
  5. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nürnberg, P., Thiele, H., Chandler, D., Höhne, W., Cunningham, M.L., Ritter, H., Leschik, G., Uhlmann, K., Mischung, C., Harrop, K., Goldblatt, J., Borochowitz, Z.U., Kotzot, D., Westermann, F., Mundlos, S., Braun, H.S., Laing, N., Tinschert, S. Nat. Genet. (2001) [Pubmed]
  6. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Clot, P., Parola, M., Bellomo, G., Dianzani, U., Carini, R., Tabone, M., Aricò, S., Ingelman-Sundberg, M., Albano, E. Gastroenterology (1997) [Pubmed]
  7. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. Anandatheerthavarada, H.K., Biswas, G., Robin, M.A., Avadhani, N.G. J. Cell Biol. (2003) [Pubmed]
  8. Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Rambukkana, A., Kunz, S., Min, J., Campbell, K.P., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Dysferlin is a plasma membrane protein and is expressed early in human development. Anderson, L.V., Davison, K., Moss, J.A., Young, C., Cullen, M.J., Walsh, J., Johnson, M.A., Bashir, R., Britton, S., Keers, S., Argov, Z., Mahjneh, I., Fougerousse, F., Beckmann, J.S., Bushby, K.M. Hum. Mol. Genet. (1999) [Pubmed]
  10. Trial of d-alpha-tocopherol in Huntington's disease. Peyser, C.E., Folstein, M., Chase, G.A., Starkstein, S., Brandt, J., Cockrell, J.R., Bylsma, F., Coyle, J.T., McHugh, P.R., Folstein, S.E. The American journal of psychiatry. (1995) [Pubmed]
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  12. Location is everything: lipid rafts and immune cell signaling. Dykstra, M., Cherukuri, A., Sohn, H.W., Tzeng, S.J., Pierce, S.K. Annu. Rev. Immunol. (2003) [Pubmed]
  13. Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Mellado, M., Rodríguez-Frade, J.M., Mañes, S., Martínez-A, C. Annu. Rev. Immunol. (2001) [Pubmed]
  14. Structure and function of fatty acid amide hydrolase. McKinney, M.K., Cravatt, B.F. Annu. Rev. Biochem. (2005) [Pubmed]
  15. A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Hyafil, F., Morello, D., Babinet, C., Jacob, F. Cell (1980) [Pubmed]
  16. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Davies, J.P., Chen, F.W., Ioannou, Y.A. Science (2000) [Pubmed]
  17. HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., Stilper, A., Willbold, D., D'Aloja, P., Sixt, M., Kolanus, J., Ott, M., Kolanus, W., Schuler, G., Baur, A.S. Mol. Cell (2004) [Pubmed]
  18. Pathogenesis of Shigella diarrhea. VII. Evidence for a cell membrane toxin receptor involving beta1 leads to 4-linked N-acetyl-D-glucosamine oligomers. Keusch, G.T., Jacewicz, M. J. Exp. Med. (1977) [Pubmed]
  19. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. Zhuang, L., Kim, J., Adam, R.M., Solomon, K.R., Freeman, M.R. J. Clin. Invest. (2005) [Pubmed]
  20. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Bennett, V., Baines, A.J. Physiol. Rev. (2001) [Pubmed]
  21. Molecular architecture and functional model of the endocytic AP2 complex. Collins, B.M., McCoy, A.J., Kent, H.M., Evans, P.R., Owen, D.J. Cell (2002) [Pubmed]
  22. Biogenesis of epithelial cell polarity: intracellular sorting and vectorial exocytosis of an apical plasma membrane glycoprotein. Misek, D.E., Bard, E., Rodriguez-Boulan, E. Cell (1984) [Pubmed]
  23. Transforming growth factor-beta controls receptor levels for epidermal growth factor in NRK fibroblasts. Assoian, R.K., Frolik, C.A., Roberts, A.B., Miller, D.M., Sporn, M.B. Cell (1984) [Pubmed]
  24. Comparative aspects of glycoprotein structure. Kornfeld, R., Kornfeld, S. Annu. Rev. Biochem. (1976) [Pubmed]
  25. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., Stanners, C.P. Cell (1989) [Pubmed]
  26. rab5 controls early endosome fusion in vitro. Gorvel, J.P., Chavrier, P., Zerial, M., Gruenberg, J. Cell (1991) [Pubmed]
  27. CD62/P-selectin recognition of myeloid and tumor cell sulfatides. Aruffo, A., Kolanus, W., Walz, G., Fredman, P., Seed, B. Cell (1991) [Pubmed]
  28. Leukotrienes. Hammarström, S. Annu. Rev. Biochem. (1983) [Pubmed]
  29. Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. Herzig, S., Neumann, J. Physiol. Rev. (2000) [Pubmed]
  30. Physiological roles and regulation of mammalian sulfate transporters. Markovich, D. Physiol. Rev. (2001) [Pubmed]
  31. Renal vacuolar H+-ATPase. Wagner, C.A., Finberg, K.E., Breton, S., Marshansky, V., Brown, D., Geibel, J.P. Physiol. Rev. (2004) [Pubmed]
  32. Cellular mechanisms of melatonin action. Vanecek, J. Physiol. Rev. (1998) [Pubmed]
  33. Lipopolysaccharide endotoxins. Raetz, C.R., Whitfield, C. Annu. Rev. Biochem. (2002) [Pubmed]
  34. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinkel, A.H., Borst, P., van Meer, G. Cell (1996) [Pubmed]
  35. Exogenous Dp71 restores the levels of dystrophin associated proteins but does not alleviate muscle damage in mdx mice. Greenberg, D.S., Sunada, Y., Campbell, K.P., Yaffe, D., Nudel, U. Nat. Genet. (1994) [Pubmed]
  36. Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency. Cherif-Zahar, B., Raynal, V., Gane, P., Mattei, M.G., Bailly, P., Gibbs, B., Colin, Y., Cartron, J.P. Nat. Genet. (1996) [Pubmed]
  37. Polar appearance and nonligand induced spreading of measles virus hemagglutinin at the surface of chronically infected cells. Ehrnst, A., Sundqvist, K.G. Cell (1975) [Pubmed]
  38. Spectrin mutations cause spinocerebellar ataxia type 5. Ikeda, Y., Dick, K.A., Weatherspoon, M.R., Gincel, D., Armbrust, K.R., Dalton, J.C., Stevanin, G., Dürr, A., Zühlke, C., Bürk, K., Clark, H.B., Brice, A., Rothstein, J.D., Schut, L.J., Day, J.W., Ranum, L.P. Nat. Genet. (2006) [Pubmed]
  39. Expression of recombinant dystrophin and its localization to the cell membrane. Lee, C.C., Pearlman, J.A., Chamberlain, J.S., Caskey, C.T. Nature (1991) [Pubmed]
  40. Failure of filipin to detect cholesterol-rich domains in smooth muscle plasma membrane. Severs, N.J., Simons, H.L. Nature (1983) [Pubmed]
  41. A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum. Imler, J.L., Schatz, C., Wasylyk, C., Chatton, B., Wasylyk, B. Nature (1988) [Pubmed]
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