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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CYFIP1  -  cytoplasmic FMR1 interacting protein 1

Homo sapiens

Synonyms: Cytoplasmic FMR1-interacting protein 1, KIAA0068, P140SRA-1, SHYC, SRA-1, ...
 
 
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High impact information on CYFIP1

  • We present here the identification of CYFIP1/2 (Cytoplasmic FMRP Interacting Proteins) as FMRP interactors [1].
  • CYFIP1/2 are proteins of unknown function, but CYFIP1 has recently been shown to interact with the small GTPase Rac1, which is implicated in development and maintenance of neuronal structures [1].
  • CYFIP1/2 share 88% amino acid sequence identity and represent the two members in humans of a highly conserved protein family [1].
  • We show here that long transcribed but untranslated CGG-repeat tracts are toxic to human cells and alter the expression of a wide variety of different genes including caspase-8, CYFIP, Neurotensin and UBE3A [2].

References

  1. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Schenck, A., Bardoni, B., Moro, A., Bagni, C., Mandel, J.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles. Handa, V., Goldwater, D., Stiles, D., Cam, M., Poy, G., Kumari, D., Usdin, K. FEBS Lett. (2005) [Pubmed]
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