Gene Review:
RAC1 - ras-related C3 botulinum toxin substrate 1...
Homo sapiens
Synonyms:
Cell migration-inducing gene 5 protein, MIG5, Rac-1, Ras-like protein TC25, Ras-related C3 botulinum toxin substrate 1, ...
- Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Gao, Y., Dickerson, J.B., Guo, F., Zheng, J., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells. Choi, S.Y., Kim, M.J., Kang, C.M., Bae, S., Cho, C.K., Soh, J.W., Kim, J.H., Kang, S., Chung, H.Y., Lee, Y.S., Lee, S.J. J. Biol. Chem. (2006)
- Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1. Zeng, H., Zhao, D., Mukhopadhyay, D. J. Biol. Chem. (2002)
- Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat. Equils, O., Madak, Z., Liu, C., Michelsen, K.S., Bulut, Y., Lu, D. J. Immunol. (2004)
- Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. Verma, A., Mohindru, M., Deb, D.K., Sassano, A., Kambhampati, S., Ravandi, F., Minucci, S., Kalvakolanu, D.V., Platanias, L.C. J. Biol. Chem. (2002)
- A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells. Espina, C., Céspedes, M.V., García-Cabezas, M.A., Gómez del Pulgar, M.T., Boluda, A., Oroz, L.G., Benitah, S.A., Cejas, P., Nistal, M., Mangues, R., Lacal, J.C. Am. J. Pathol. (2008)
- Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis. Nod??-Langlois, R., Muller, D., Boda, B. J. Cell. Sci. (2006)
- Identification of a bacterial type III effector family with G protein mimicry functions. Alto, N.M., Shao, F., Lazar, C.S., Brost, R.L., Chua, G., Mattoo, S., McMahon, S.A., Ghosh, P., Hughes, T.R., Boone, C., Dixon, J.E. Cell (2006)
- Distinct Behavioral Responses to Ethanol Are Regulated by Alternate RhoGAP18B Isoforms. Rothenfluh, A., Threlkeld, R.J., Bainton, R.J., Tsai, L.T., Lasek, A.W., Heberlein, U. Cell (2006)
- NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Liu, X., Wang, H., Eberstadt, M., Schnuchel, A., Olejniczak, E.T., Meadows, R.P., Schkeryantz, J.M., Janowick, D.A., Harlan, J.E., Harris, E.A., Staunton, D.E., Fesik, S.W. Cell (1998)
- The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Coso, O.A., Chiariello, M., Yu, J.C., Teramoto, H., Crespo, P., Xu, N., Miki, T., Gutkind, J.S. Cell (1995)
- Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Eden, S., Rohatgi, R., Podtelejnikov, A.V., Mann, M., Kirschner, M.W. Nature (2002)
- HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma. Turcotte, S., Desrosiers, R.R., Béliveau, R. J. Cell. Sci. (2003)
- Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Martinez, J.J., Hultgren, S.J. Cell. Microbiol. (2002)
- Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells. Nikolova, S., Lee, Y.S., Lee, Y.S., Kim, J.A. Free Radic. Res. (2005)
- Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells. Sarner, S., Kozma, R., Ahmed, S., Lim, L. Mol. Cell. Biol. (2000)
- Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Asai, N., Fukuda, T., Wu, Z., Enomoto, A., Pachnis, V., Takahashi, M., Costantini, F. Development (2006)
- Characterization of small GTPases Cdc42 and Rac and the relationship between Cdc42 and actin cytoskeleton in vegetative and ectomycorrhizal hyphae of Suillus bovinus. Gorfer, M., Tarkka, M.T., Hanif, M., Pardo, A.G., Laitiainen, E., Raudaskoski, M. Mol. Plant Microbe Interact. (2001)
- Matos P, Oliveira C, Velho S, Gonçalves V, et al. (2008). B-RafV600E cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. Gastroenterology, 135, 899-906.
WikiGenes . Publication - Endotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways. Lin, F.Y., Chen, Y.H., Tasi, J.S., Chen, J.W., Yang, T.L., Wang, H.J., Li, C.Y., Chen, Y.L., Lin, S.J. Arterioscler. Thromb. Vasc. Biol. (2006)
- Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Asanuma, K., Yanagida-Asanuma, E., Faul, C., Tomino, Y., Kim, K., Mundel, P. Nat. Cell Biol. (2006)
- Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. Wang, H., Yang, C., Leskow, F.C., Sun, J., Canagarajah, B., Hurley, J.H., Kazanietz, M.G. EMBO J. (2006)
- A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. Martin, G.A., Bollag, G., McCormick, F., Abo, A. EMBO J. (1995)
- Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. ten Klooster, J.P., Jaffer, Z.M., Chernoff, J., Hordijk, P.L. J. Cell Biol. (2006)
- DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. Nishihara, H., Maeda, M., Oda, A., Tsuda, M., Sawa, H., Nagashima, K., Tanaka, S. Blood (2002)
- Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Clerk, A., Pham, F.H., Fuller, S.J., Sahai, E., Aktories, K., Marais, R., Marshall, C., Sugden, P.H. Mol. Cell. Biol. (2001)
- Down-regulation of Rac activity during beta 2 integrin-mediated adhesion of human neutrophils. Dib, K., Melander, F., Axelsson, L., Dagher, M.C., Aspenström, P., Andersson, T. J. Biol. Chem. (2003)
- Rho family GTPases bind to phosphoinositide kinases. Tolias, K.F., Cantley, L.C., Carpenter, C.L. J. Biol. Chem. (1995)
- The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. Kligys, K., Claiborne, J.N., DeBiase, P.J., Hopkinson, S.B., Wu, Y., Mizuno, K., Jones, J.C. J. Biol. Chem. (2007)
- Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Diekmann, D., Abo, A., Johnston, C., Segal, A.W., Hall, A. Science (1994)
- Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. Zhang, B., Chernoff, J., Zheng, Y. J. Biol. Chem. (1998)
- Nox1-dependent reactive oxygen generation is regulated by Rac1. Cheng, G., Diebold, B.A., Hughes, Y., Lambeth, J.D. J. Biol. Chem. (2006)
- Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes. Koivisto, L., Häkkinen, L., Matsumoto, K., McCulloch, C.A., Yamada, K.M., Larjava, H. Exp. Cell Res. (2004)
- A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Schenck, A., Bardoni, B., Moro, A., Bagni, C., Mandel, J.L. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes. Gringhuis, S.I., de Leij, L.F., Coffer, P.J., Vellenga, E. Mol. Cell. Biol. (1998)
- FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for betaPIX. Chang, F., Lemmon, C.A., Park, D., Romer, L.H. Mol. Biol. Cell (2007)
- ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. Radhakrishna, H., Al-Awar, O., Khachikian, Z., Donaldson, J.G. J. Cell. Sci. (1999)
- AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration. Autieri, M.V., Kelemen, S.E., Wendt, K.W. Circ. Res. (2003)
- Kinectin is a key effector of RhoG microtubule-dependent cellular activity. Vignal, E., Blangy, A., Martin, M., Gauthier-Rouvière, C., Fort, P. Mol. Cell. Biol. (2001)
- Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation. Bourguignon, L.Y., Singleton, P.A., Diedrich, F. J. Biol. Chem. (2004)
- Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility. Ueda, Y., Wang, S., Dumont, N., Yi, J.Y., Koh, Y., Arteaga, C.L. J. Biol. Chem. (2004)
- Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism. Nerlich, A., Rohde, M., Talay, S.R., Genth, H., Just, I., Chhatwal, G.S. J. Biol. Chem. (2009)
- Regulation of Akt-dependent cell survival by Syk and Rac. Jiang, K., Zhong, B., Ritchey, C., Gilvary, D.L., Hong-Geller, E., Wei, S., Djeu, J.Y. Blood (2003)
- Characterization of RAC3, a novel member of the Rho family. Haataja, L., Groffen, J., Heisterkamp, N. J. Biol. Chem. (1997)
- A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils. Prigmore, E., Ahmed, S., Best, A., Kozma, R., Manser, E., Segal, A.W., Lim, L. J. Biol. Chem. (1995)
- Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. Han, Q., Leng, J., Bian, D., Mahanivong, C., Carpenter, K.A., Pan, Z.K., Han, J., Huang, S. J. Biol. Chem. (2002)
- Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway. Kiian, I., Tkachuk, N., Haller, H., Dumler, I. Thromb. Haemost. (2003)
- Activation of the small GTPase Rac1 by cGMP-dependent protein kinase. Hou, Y., Ye, R.D., Browning, D.D. Cell. Signal. (2004)
- Small GTPase Rac1: structure, localization, and expression of the human gene. Matos, P., Skaug, J., Marques, B., Beck, S., Veríssimo, F., Gespach, C., Boavida, M.G., Scherer, S.W., Jordan, P. Biochem. Biophys. Res. Commun. (2000)
- Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase. Tamura, M., Kai, T., Tsunawaki, S., Lambeth, J.D., Kameda, K. Biochem. Biophys. Res. Commun. (2000)