Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

DOCK9 - dedicator of cytokinesis 9

Homo sapiens

Synonyms: Cdc42 guanine nucleotide exchange factor zizimin-1, Dedicator of cytokinesis protein 9, KIAA1058, ZIZ1, ZIZIMIN1

Meller, N. et al.

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High impact information on DOCK9

Deletion and mutation analysis indicated existence of individual Cdc42-binding sites in the zizimin1 monomers [1].

Associations of DOCK9 with chemical compounds

The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain [1].

Other interactions of DOCK9

Kinetic measurements demonstrated increased binding affinity of Cdc42 to zizimin1 at higher Cdc42 concentration, suggesting positive cooperativity [1].

Analytical, diagnostic and therapeutic context of DOCK9

Rotary shadowing electron microscopy revealed zizimin1 to be a symmetric, V-shaped molecule [1].

References

The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. Meller, N., Irani-Tehrani, M., Ratnikov, B.I., Paschal, B.M., Schwartz, M.A. J. Biol. Chem. (2004) [Pubmed]

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AgaP_AGAP008535	Anopheles gambiae str. PEST
DOCK9	Bos taurus
F22G12.5	Caenorhabditis elegans
F22G12.5	Caenorhabditis elegans
DOCK9	Canis lupus familiaris
dock9b	Danio rerio
Ziz	Drosophila melanogaster
DOCK9	Gallus gallus
DOCK9	Macaca mulatta
Dock9	Mus musculus
DOCK9	Pan troglodytes
Dock9	Rattus norvegicus

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